Technical Note: Bone mineral density measurements of strontium‐rich trabecular bone‐mimicking phantoms using quantitative ultrasound

Rizvi, Bisma; Silva, Éric Da; Slatkovska, Luba; Cheung, Angela M.; Tavakkoli, Jahan; Pejović‐Milić, Ana

doi:10.1118/1.4963805

Cited by 5 publications

(11 citation statements)

References 75 publications

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“…The difference can be attributed to the lack of porous microstructure of bone matrix in the developed homogeneous bone‐mimicking phantom, as BUA is not only affected by bone material but also by its microarchitecture . However, the phantom can be considered as a good representation of human calcaneus, as a strong positive linear correlation between BUA and vBMD of the bone‐mimicking phantom has been demonstrated by Rizvi and colleagues …”

Section: Discussionsupporting

confidence: 90%

“…The protocol developed by Rizvi and colleagues was used to produce the gelatin‐based bone phantoms. Once the hydroxyapatite phantoms were set, they were dried to constant weight at 80°C and then were finely powdered using a tungsten carbide ball mill.…”

Section: Methodsmentioning

confidence: 99%

“…The nominal frequency of the transducers was 0.6 MHz, and the frequency range used to measure BUA was 0.2 to 0.6 MHz. Because the two ultrasound transducers of the QUS system apply mechanical pressure that can compress and thus damage the gelatin‐based phantom, a multilayer QUS phantom was developed by Rizvi and colleagues to protect the gelatin‐based phantom from the pressure. The gelatin‐based phantom was housed in an acrylic box with a thin Mylar window to allow the transmission of ultrasound.…”

Section: Methodsmentioning

confidence: 99%

“…Our research group has previously developed a bone‐mimicking phantom by synthesizing pure hydroxyapatite without contamination of strontium and lead and hydroxyapatite with controlled substitution of strontium . More recently, Rizvi and colleagues further developed a bone‐mimicking phantom for QUS measurements, by suspending the finely powdered hydroxyapatite homogeneously in gelatinous medium.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the effect of strontium, lead, and aluminum in bone on dual‐energy x‐ray absorptiometry and quantitative ultrasound measurements: A phantom study

et al. 2017

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Purpose: Dual-energy X-ray absorptiometry (DXA) is the gold standard technique to measure areal bone mineral density (aBMD) for the diagnosis of osteoporosis. Because DXA relies on the attenuation of photon to estimate aBMD, deposition of bone-seeking metallic elements such as strontium, lead, and aluminum that differ in atomic numbers from calcium can cause inaccurate estimation of aBMD. Quantitative ultrasound (QUS) is another technique available to assess bone health by measuring broadband ultrasound attenuation (BUA), speed of sound (SOS), and an empirically derived quantity called stiffness index (SI). Because the acoustic properties are not prone to significant change due to changes in microscopic atomic composition of bone, it is hypothesized that QUS is unaffected by the presence of bone-seeking elements in the bone. The objective of this study was to investigate the effect of strontium, lead, and aluminum on DXA-derived aBMD and QUS parameters using bone-mimicking phantoms compatible with both techniques. Methods: Bone-mimicking phantoms were produced by homogeneously mixing finely powdered hydroxyapatite compounds that contain varying concentrations of strontium, lead, or aluminum with porcine gelatin solution. Seven strontium-substituted phantoms were produced with varying molar ratio of Sr/ (Sr + Ca) ranging from 0% to 2%. Four lead-doped phantoms and four aluminum-doped phantoms were constructed with the respective analyte concentrations ranging from 50 to 200 ppm. An additional 0 ppm phantom was produced to be used as a baseline for the lead and aluminum phantom measurements. All phantoms had uniform volumetric bone mineral density (vBMD) of 200 mg/cm 3 , and were assessed using a Hologic Horizon â DXA device and a Hologic Sahara â QUS device. Furthermore, theoretical aBMD bias for mol/mol% substitution of calcium with the three bone-seeking elements was calculated. Results: Strong positive linear relationship was found between aBMD measured by DXA and strontium concentration (P < 0.001, r = 0.995). From the measurement of lead and aluminum phantoms using DXA, no statistically significant relationship was observed between aBMD and the analyte concentrations. For the QUS system, with an exception of BUA and lead concentration that exhibited statistically significant relationship (P < 0.038, r = 0.899), no statistically significant change was observed in all QUS parameters with respect to the clinically relevant concentration of all three elements. The calculated theoretical aBMD bias induced by 1 mol/mol% substitution of calcium with strontium, lead, and aluminum were 10.8%, 4.6%, and À0.7%, respectively. Conclusion: aBMD measured by DXA was prone to overestimation in the presence of strontium, but acoustic parameters measured by QUS are independent of strontium concentration. The deviation in aBMD induced by the clinically relevant concentrations of lead and aluminum under 200 ppm could not be detected using the Hologic Horizon â DXA device. Furthermore, the SI measured by the QUS system was not af...

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Section: Discussionsupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of the effect of strontium, lead, and aluminum in bone on dual‐energy x‐ray absorptiometry and quantitative ultrasound measurements: A phantom study

et al. 2017

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“…The protocol developed by Rizvi and colleagues (65,66) was used to produce the gelatin-based trabecular bone phantoms. Once the hydroxyapatite phantoms were set, they were dried to constant weight at 80 ºC and then were finely powdered using a tungsten carbide ball mill.…”

Section: Hydroxyapatite-based Trabecular Bone-mimicking Phantommentioning

confidence: 99%

Assessment of the effect of strontium, lead and aluminum on dual-energy x-ray absorptiometry and quantitative ultrasound using trabecular bone-mimicking phantoms

Jang¹

2023

Preprint

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Dual-energy X-ray absorptiometry (DXA) is the gold standard of bone densitometry. However, inaccurate estimation of areal bone mineral density (aBMD) is of concern when calcium in bone mineral is partially substituted with bone-seeking elements such as strontium, lead and aluminum. Quantitative ultrasound (QUS) is an alternative bone densitometry technique that can assess bone health based on the measurement of acoustic parameters. This study aims to investigate the effect of the clinically relevant concentrations of bone-seeking elements on aBMD measured by DXA and the acoustic parameters measured by QUS, using trabecular bone-mimicking phantoms. Statistically significant linear relationship was observed between aBMD and strontium concentration. For clinically relevant concentrations of lead and aluminum, the deviation in aBMD measurements was within 1% coefficient of variation of DXA. No statistically significant deviation was observed in stiffness index measurement by QUS in the presence of any of the three bone-seeking elements

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Structural and Metabolic Assessment of Bone

Narla

Ott

2020

Bone Regulators and Osteoporosis Therapy

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Technical Note: Bone mineral density measurements of strontium‐rich trabecular bone‐mimicking phantoms using quantitative ultrasound

Cited by 5 publications

References 75 publications

Assessment of the effect of strontium, lead, and aluminum in bone on dual‐energy x‐ray absorptiometry and quantitative ultrasound measurements: A phantom study

Assessment of the effect of strontium, lead, and aluminum in bone on dual‐energy x‐ray absorptiometry and quantitative ultrasound measurements: A phantom study

Assessment of the effect of strontium, lead and aluminum on dual-energy x-ray absorptiometry and quantitative ultrasound using trabecular bone-mimicking phantoms

Structural and Metabolic Assessment of Bone

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