Technical performance of shear wave elastography for measuring liver stiffness in pediatric and adolescent patients: a systematic review and meta-analysis

Kim, Dong Wook; Park, Chan; Yoon, Hyung Ku; Jung, Ah Young; Lee, Jin Seong; Jung, Sung Eun; Cho, Young Ah

doi:10.1007/s00330-018-5900-6

Cited by 15 publications

(9 citation statements)

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“…Technical failure and unreliable measurement rates of 2D-SWE were 1.9%in this study, which was relatively low. In the meta-analysis, the technical failure of 2D-SWE was reported as 2.2%, which was significantly lower than that of TE (12.1%) or 1D-SWE (4.1%) [32]. This is probably due to the characteristics of 2D-SWE that can be directly measured while observing B-mode images.…”

Section: Discussionmentioning

confidence: 90%

The Diagnostic Accuracy of LOGIQ S8 and E9 Shear Wave Elastography for Staging Hepatic Fibrosis, in Comparison with Transient Elastography

Yoo

Kim

2021

Diagnostics

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Background: The aim of this study was to evaluate the usefulness of two different types of 2-dimensional shear wave elastography (2D-SWE) for predicting liver fibrosis stages in comparison to transient elastography (TE), using a histologic METAVIR scoring system as the reference method. Methods: A total of 203 patients with chronic liver disease were prospectively enrolled in the study. Two different 2D-SWEs (LOGIQ S8 and E9 systems, GE Healthcare, Chalfont St Giles, UK) were assessed for liver stiffness in patients with chronic liver diseases. Patients received 2D-SWE examinations with the S8 and E9 systems, and also underwent TE (FibroScan®, Echosens, France) tests and liver biopsies on the same day. Results: The most common etiology of chronic liver disease was non-alcoholic fatty liver disease (28.7%), followed by chronic hepatitis B (25.1%). Liver fibrosis stages consisted of F0 (22.6%), F1 (29.7%), F2 (16.9%), F3 (12.8%) and F4 (17.9%). Overall, S8 and E9 were well correlated with the histologic fibrosis stages. The optimal cut-off values for S8 and E9 to differentiate significant fibrosis (≥F2) were 6.70 kPa and 6.42 kPa, respectively, while the cut-off values for S8 and E9 in distinguishing liver cirrhosis were 9.15 kPa and 8.88 kPa, respectively. Among the 195 patients who had successful measurements in both S8 and E9, liver stiffness showed good inter-equipment correlation (ICC: 0.900, p < 0.001). Regarding diagnostic ability, upon comparison (FibroScan®), there were no significant differences between 2D-SWEs and TE for detecting every stage of liver fibrosis. Conclusion: In comparison to TE, 2D-SWE with LOGIQ S8 and E9 (GE Healthcare) are useful non-invasive tools for predicting significant fibrosis and liver cirrhosis.

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Section: Discussionmentioning

confidence: 90%

The Diagnostic Accuracy of LOGIQ S8 and E9 Shear Wave Elastography for Staging Hepatic Fibrosis, in Comparison with Transient Elastography

Yoo

Kim

2021

Diagnostics

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“…Furthermore, various factors, such as fasting time, breathing, and BMI, can substantially affect the measurement of shear wave velocities and, therefore, must be taken into account when interpreting the results[ 5 ]. A recent meta-analysis of 2D-SWE reconfirmed the higher reliability of the method compared to the other ultrasound elastography methods as demonstrated in various studies[ 6 ].…”

Section: Introductionmentioning

confidence: 78%

“…A newer generation of elastography techniques that do not require mechanical pulses to generate shear waves, but instead use high-intensity ultrasound waves, is summarized as acoustic radiation force impulse (ARFI) elastography. Compared to TE, ARFI techniques are more precise and allow more valid measurements, even in patients with high body mass index (BMI) or ascites[ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Different manufacturers have increasingly integrated p-SWE and 2D-SWE techniques into their ultrasound scanners. In a meta-analysis, the pSWE and 2D-SWE techniques showed significantly better results than FibroScan with respect to the rate of unreliable measurements in healthy subjects and in patients with chronic liver disease[ 6 ]. However, some of the study populations examined in the comparative studies were small and, often, only two different ultrasound devices from different manufacturers were compared[ 7 - 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of point and two-dimensional shear wave elastography of the spleen in healthy subjects

Nowotny¹,

Schmidberger²,

Schlingeloff³

et al. 2021

WJR

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BACKGROUND Few systematic comparative studies of the different methods of physical elastography of the spleen are currently available. AIM To compare point shear wave and two-dimensional elastography of the spleen considering the anatomical location (upper, hilar, and lower pole). METHODS As part of a prospective clinical study, healthy volunteers were examined for splenic elasticity using four different ultrasound devices between May 2015 and April 2017. The devices used for point shear wave elastography were from Siemens (S 3000) and Philips (Epiq 7), and those used for two-dimensional shear wave elastography were from GE (Logiq E9) and Toshiba (Aplio 500). In addition, two different software versions (5.0 and 6.0) were evaluated for the Toshiba ultrasound device (Aplio 500). The study consisted of three arms: A, B, and C. RESULTS In study arm A, 200 subjects were evaluated (78 males and 122 females, mean age 27.9 ± 8.1 years). In study arm B, 113 subjects were evaluated (38 men and 75 women, mean age 26.0 ± 6.3 years). In study arm C, 44 subjects were enrolled. A significant correlation of the shear wave velocities at the upper third of the spleen ( r = 0.33088, P < 0.0001) was demonstrated only for the Philips Epiq 7 device compared to the Siemens Acuson S 3000. In comparisons of the other ultrasound devices (GE, Siemens, Toshiba), no comparable results could be obtained for any anatomical position of the spleen. The influencing factors age, gender, and body mass index did not show a clear correlation with the measured shear wave velocities. CONCLUSION The absolute values of the shear wave elastography measurements of the spleen and the two different elastography methods are not comparable between different manufacturers or models.

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“…Two newer sonographic methods for fibrosis detection, point and two-dimensional share wave elastography, have been shown to have low levels of technical failure and have been comparable [ 34 ]. The same meta-analysis reported that transient elastography was unreliable in 12.1% of measurements in children and adolescents.…”

Section: Resultsmentioning

confidence: 99%

Non-Alcoholic Fatty Liver Disease in Children

Brecelj

Orel

2021

Medicina

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Background and Objectives: The prevalence of pediatric non-alcoholic fatty liver disease is increasing. A lot of new data are published regularly. Materials and Methods: Original clinical studies, review articles, and guidelines in children were searched for and the most relevant included in this review. Results: A total of 138 retrieved papers were classified into pathogenesis, epidemiology, diagnosis, and treatment. Pathogenesis is currently explained with the “multi hit hypothesis”, with complex interactions of genetic and environmental factors which trigger inflammation in steatotic liver. The prevalence is rising. A diagnosis can be made with laboratory tests, imaging, and liver biopsy after the exclusion of other causes of liver steatosis. The mainstay of treatment is lifestyle modification consisting of dietary intervention and increased physical activity. The progression to liver cirrhosis can occur even in children. Conclusions: Non-alcoholic fatty liver disease in children is a part of a metabolic syndrome in the majority of patients. Due to its complex etiology and high prevalence, multidisciplinary teams, together with public health professionals, should be involved in its treatment.

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Technical performance of shear wave elastography for measuring liver stiffness in pediatric and adolescent patients: a systematic review and meta-analysis

Cited by 15 publications

References 50 publications

The Diagnostic Accuracy of LOGIQ S8 and E9 Shear Wave Elastography for Staging Hepatic Fibrosis, in Comparison with Transient Elastography

The Diagnostic Accuracy of LOGIQ S8 and E9 Shear Wave Elastography for Staging Hepatic Fibrosis, in Comparison with Transient Elastography

Comparison of point and two-dimensional shear wave elastography of the spleen in healthy subjects

Non-Alcoholic Fatty Liver Disease in Children

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