To ensure sufficient thermal performance within electric vehicle (EV) batteries, thermal interface materials (TIMs), such as pastes or adhesives, are widely used to fill thermally insulating voids between cells and cooling components. However, TIMs are composite materials that are subject to degradation over the battery’s lifetime. Using TIMs for battery applications is a new and emerging topic, creating the need to rapidly acquire knowledge about appropriate lifetime testing and evaluation methods, in close collaboration with the battery manufacturers. This paper reviews suitable methods for durability testing as well as basic modeling approaches which allow for the transfer of laboratory results to the longtime behavior of interface materials during a vehicle’s lifetime.