Technique of Intracranial Electrode Implacement for Recording and Stimulation and its Possible Therapeutic Value in Psychotic Patients

Delgado, José M. R.; Hamlin, Hannibal; Chapman, William P.

doi:10.1159/000105792

Cited by 101 publications

(58 citation statements)

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“…However, the literature reveals that the use of long-term electrical stimulation at deep brain targets was explored as early as the 1950s. 51 The reversibility of treatment effects was noted by Irving Cooper in the 1970s. 241 The fact remains, however, that the safety and efficacy of DBS as a therapeutic modality was established by its use in the treatment of movement disorders.…”

Section: 220mentioning

confidence: 96%

Deep brain stimulation for psychiatric disorders: where we are now

Cleary

Ozpinar

Raslan

et al. 2015

FOC

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Fossil records showing trephination in the Stone Age provide evidence that humans have sought to influence the mind through physical means since before the historical record. Attempts to treat psychiatric disease via neurosurgical means in the 20th century provided some intriguing initial results. However, the indiscriminate application of these treatments, lack of rigorous evaluation of the results, and the side effects of ablative, irreversible procedures resulted in a backlash against brain surgery for psychiatric disorders that continues to this day. With the advent of psychotropic medications, interest in invasive procedures for organic brain disease waned. Diagnosis and classification of psychiatric diseases has improved, due to a better understanding of psychiatric patho-physiology and the development of disease and treatment biomarkers. Meanwhile, a significant percentage of patients remain refractory to multiple modes of treatment, and psychiatric disease remains the number one cause of disability in the world. These data, along with the safe and efficacious application of deep brain stimulation (DBS) for movement disorders, in principle a reversible process, is rekindling interest in the surgical treatment of psychiatric disorders with stimulation of deep brain sites involved in emotional and behavioral circuitry. This review presents a brief history of psychosurgery and summarizes the development of DBS for psychiatric disease, reviewing the available evidence for the current application of DBS for disorders of the mind.

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Section: 220mentioning

confidence: 96%

Deep brain stimulation for psychiatric disorders: where we are now

Cleary

Ozpinar

Raslan

et al. 2015

FOC

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“…The first therapeutic brain stimulation efforts were made by Delgado et al (1952) and Heath (1963) in the field of psychiatry [69,70] . In 1979, a New York-based neurosurgeon, Irving Cooper carried out the first deep brain thalamic electrical stimulation for the treatment of epilepsy.…”

Section: Other Methodsmentioning

confidence: 99%

An Overview of Non-drug Therapies for the Treatment of Epilepsy

Yasam¹,

Jakki²,

Senthil³

et al. 2018

pharmaceutical-sciences

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Yasam, et al.: Epilepsy and Non-drug TherapiesEpilepsy is one of the most common neurological disorders, characterized by recurrent spontaneous seizures and a major health problem that affects around 1-2 % of the population worldwide. The treatment generally includes antiepileptic drug therapies. However, despite the development of various antiepileptic drugs, about a third of patients are resistant to current pharmacotherapies. Non-drug therapies are also expanding in an exciting and unprecedented way since in patients with drug resistance, non-drug therapies like surgeries; implantable devices and diet are playing a key role in improving the quality of patient's life. In this review, the current available non-drug therapies ranging from preclinical to clinical for controlling seizures in epileptic patients with drug resistance have been highlighted. Initial results from these therapies are quite promising, but considerable development is required before these treatments earn a place in the standard clinical care.

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“…The fact that frequency influenced activity was also appreciated by the end of the 1950s [53,57,165,196,[211][212][213][214][215][216][217]. Electrical stimulation was used, for among other things, to isolate the exact area to lesion.…”

Section: Gabriel and Nashold Statementioning

confidence: 99%

The Development of Deep Brain Stimulation for Movement Disorders

Greek¹

2012

J Clinic Res Bioeth

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The development of deep brain stimulation has revolutionized care for patients with movement disorders like Parkinson's disease. Many areas of science contributed to this technology but one area, the use of animal models, has been cited as vital. We review these claims as well as the history of the discoveries that eventually led to deep brain stimulation in an attempt to ascertain: 1) the contributions of animal models; 2) the contributions from humanbased research and observation; and the role of advances in the engineering, physics, and computer science. We distinguish between advances and discoveries that were, or at least appear to be, dependent on animal models and those where animals were involved but that could have occurred, and/or were occurring simultaneously, with humanbased research. We conclude that animal-based research played a role in defining gross anatomy in the 19 th and early 20 th centuries, but that essentially all subsequent advances were human-based or secondary to advances in the physical and applied sciences. This has historical, funding, and ethical implications as the development of deep brain stimulation is cited as an example of the importance of animal-based research and a reason for continued social and financial support of animal models in general as opposed to clinical research, other human-based research modalities, and the various disciplines of the physical and applied sciences.

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Technique of Intracranial Electrode Implacement for Recording and Stimulation and its Possible Therapeutic Value in Psychotic Patients

Cited by 101 publications

References 0 publications

Deep brain stimulation for psychiatric disorders: where we are now

Deep brain stimulation for psychiatric disorders: where we are now

An Overview of Non-drug Therapies for the Treatment of Epilepsy

The Development of Deep Brain Stimulation for Movement Disorders

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