1975
DOI: 10.1530/acta.0.080s262
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Techniques for Eliciting Mucosal Immune Response

Abstract: Development of techniques for eliciting an immune response on mucosal surfaces is a relatively new area of clinical research. With the recognition of the existence of secretory immunity, independent of the systemic system, there was renewed interest in re-examining the conventional approach for optimal immunization techniques. A large body of data indicate that the majority of the secretory immunoglobulins and antibody produced to antigenic stimulation of mucosal surfaces is locally produced. Thus, antibody to… Show more

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Cited by 7 publications
(6 citation statements)
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“…The amount of antibody in uterine fluid is regulated by steroid hormones, with larger amounts of both immunoglobulin classes being present in rat uterine fluid during oestrus or oestradiol treatment than during dioestrus or progesterone treatment (Wira & Sullivan, 1982). In the secretions of other mucosal tissues, including the mouse vagina (Parr et al, 1988), the titre of specific antibody is influenced by the route of immunization, with local application of antigen to the mucosal surface often being most effective in stimulating specific IgA secretion (Waldman & Ganguly, 1974;Bienenstock, 1986). However, data on specific antibody titres in uterine fluid after immunization by different routes are not available for any species.…”
Section: Introductionmentioning
confidence: 99%
“…The amount of antibody in uterine fluid is regulated by steroid hormones, with larger amounts of both immunoglobulin classes being present in rat uterine fluid during oestrus or oestradiol treatment than during dioestrus or progesterone treatment (Wira & Sullivan, 1982). In the secretions of other mucosal tissues, including the mouse vagina (Parr et al, 1988), the titre of specific antibody is influenced by the route of immunization, with local application of antigen to the mucosal surface often being most effective in stimulating specific IgA secretion (Waldman & Ganguly, 1974;Bienenstock, 1986). However, data on specific antibody titres in uterine fluid after immunization by different routes are not available for any species.…”
Section: Introductionmentioning
confidence: 99%
“…Waldman et al (24) reported the existence of secretary IgA in cervicovaginal secretions and the IgA nature of antibodies to C. albicans. Thus, the detection of secretary IgA antibodies to C. albicans in the sera of patients with vaginal candidiasis not only confirms the importance of local stimulation and regional response in mucocutaneous infections (11,22,23,25), but also raises important considerations as to the possibility of a significant back-flow into systemic circulation of antibodies produced by perimucosal immunocytes. An alternative possibility would be the reabsorption of secreted antibody due to local inflammation and increased vascular permeability.…”
Section: Discussionmentioning
confidence: 56%
“…Antisera specific for human IgG (G), IgA (A), IgM (M), and albumin (Alb) were used in the central wells. MA, Fractions 21-23; MB, [24][25][26]MC,[27][28][29]MD,[30][31]ME,[32][33][34]MF,[35][36][37] toms carry circulating antibodies in serum with titers from 0 to 16 (Table 1). This is in accordance with the reports of Dolan and Stried (6) and Lehner (15, 16), who demonstrated antibody titers of 8 to 16 in normal subjects.…”
Section: Discussionmentioning
confidence: 99%
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“…A LMOST THIRTY YEARS AGO, Waldman and Ganguly wrote that "development of techniques for eliciting an immune response on mucosal surfaces is a relatively new area of clinical research" (157). Remarkably, this statement remains accurate even today.…”
Section: Introductionmentioning
confidence: 99%