Techniques for Measuring Endocrine Disruption in Insects

Weltje, Lennart

doi:10.1002/9781118355961.ch4

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…silkworms and honeybees) and for the development of insecticides. In particular, the functions of the insect hormones (hydroxy-)ecdysone and juvenile hormone are well-understood, and various insecticides known as insect growth regulators (IGRs) have been specifically developed to disrupt these systems (Weltje 2013). This is not the place to discuss the effects of these insecticides on target arthropod pests, but it would be relevant to summarize their unintended effects on non-target insects and other arthropods such as crustaceans which share similar hormone systems.…”

Section: Impacts On Invertebratesmentioning

confidence: 99%

A review of the evidence for endocrine disrupting effects of current-use chemicals on wildlife populations

Matthiessen¹,

Wheeler²,

Weltje³

2017

Critical Reviews in Toxicology

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114

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This review critically examines the data on claimed endocrine-mediated adverse effects of chemicals on wildlife populations. It focuses on the effects of current-use chemicals, and compares their apparent scale and severity with those of legacy chemicals which have been withdrawn from sale or use, although they may still be present in the environment. The review concludes that the effects on wildlife of many legacy chemicals with endocrine activity are generally greater than those caused by current-use chemicals, with the exception of ethinylestradiol and other estrogens found in sewage effluents, which are causing widespread effects on fish populations. It is considered that current chemical testing regimes and risk assessment procedures, at least those to which pesticides and biocides are subjected, are in part responsible for this improvement. This is noteworthy as most ecotoxicological testing for regulatory purposes is currently focused on characterizing apical adverse effect endpoints rather than identifying the mechanism(s) responsible for any observed effects. Furthermore, a suite of internationally standardized ecotoxicity tests sensitive for potential endocrine-mediated effects is now in place, or under development, which should ensure further characterization of substances with these properties so that they can be adequately regulated.

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Section: Impacts On Invertebratesmentioning

confidence: 99%

A review of the evidence for endocrine disrupting effects of current-use chemicals on wildlife populations

Matthiessen¹,

Wheeler²,

Weltje³

2017

Critical Reviews in Toxicology

Self Cite

114

View full text Add to dashboard Cite

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Commentary: Assessing the endocrine disrupting effects of chemicals on invertebrates in the European Union

et al. 2022

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Evidence from both laboratory and field studies has shown that currently used synthetic and naturally occurring chemical substances may potentially disrupt invertebrate endocrine systems, although the extent of this in field populations remains unclear. Translating concerns about potential endocrine disrupting chemicals (EDCs) into practical and effective regulatory action is currently hampered by the breadth of invertebrate endocrinology when compared to the better understood vertebrate systems, a lack of fundamental knowledge about the endocrinology of many invertebrate groups, and the resulting uncertainty when making regulatory decisions. This commentary (i) outlines the breadth of invertebrate endocrine pathways for which European Union regulation of potential EDCs may be relevant; (ii) reviews the extent to which current knowledge meets regulatory requirements for invertebrates, including an assessment of the suitability of current invertebrate test guidelines for detecting endocrine modes of action; and (iii) proposes a roadmap towards the regulation of potential EDCs with greater confidence, based on the Adverse Outcome Pathway (AOP) concept and a focus on identifying Molecular Initiating Events (MIEs) within AOPs. We conclude there are no validated tools to determine any invertebrate endocrine mode of action in vitro or in vivo. However, there are commonly used invertebrate toxicity tests which might capture adverse effects that could potentially result from an endocrine mode of action but would not identify the causal mechanisms. Therefore, EU regulatory requirements for the identification of EDCs cannot currently be satisfied for invertebrates, either in general or for the specific invertebrates used in standard ecotoxicological studies. We propose that the most important research need is compilation of a comprehensive list of endocrine-related MIEs across invertebrate taxa via use of high-throughput ‘omics in combination with bioinformatics reverse engineered analyses. Although tractable, such an approach would require significant resource investment for development and implementation.

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Techniques for Measuring Endocrine Disruption in Insects

Cited by 2 publications

References 34 publications

A review of the evidence for endocrine disrupting effects of current-use chemicals on wildlife populations

A review of the evidence for endocrine disrupting effects of current-use chemicals on wildlife populations

Commentary: Assessing the endocrine disrupting effects of chemicals on invertebrates in the European Union

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