2015
DOI: 10.3791/52348
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Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks

Abstract: Retinal prostheses for the treatment of certain forms of blindness are gaining traction in clinical trials around the world with commercial devices currently entering the market. In order to evaluate the safety of these devices, in preclinical studies, reliable techniques are needed. However, the hard metal components utilised in some retinal implants are not compatible with traditional histological processes, particularly in consideration for the delicate nature of the surrounding tissue. Here we describe tec… Show more

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Cited by 5 publications
(3 citation statements)
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“…Once the device was seen to gently touch the retina, the tack was inserted using the same forceps. The tack length was chosen such that the head would penetrate the retina, choroid and sclera [26]. If a magnetic attachment was used, the device was simply advanced towards the retina with the surgeon aligning the epiretinal magnet visually with the approximate position of the suprachoroidal magnet.…”
Section: Surgerymentioning
confidence: 99%
“…Once the device was seen to gently touch the retina, the tack was inserted using the same forceps. The tack length was chosen such that the head would penetrate the retina, choroid and sclera [26]. If a magnetic attachment was used, the device was simply advanced towards the retina with the surgeon aligning the epiretinal magnet visually with the approximate position of the suprachoroidal magnet.…”
Section: Surgerymentioning
confidence: 99%
“…Recent immunohistochemical techniques describe the evaluation of the tissue response with microelectrodes in situ (228, 229). Techniques are also available for the in situ inspection of macroelectrodes, although the approach is more limited in terms of resolution and tissue staining (230).…”
Section: In Vivo Preclinical Safety and Efficacy Studiesmentioning
confidence: 99%
“…In recent decades, the development of microelectronics has provided opportunities for the miniaturization of neural implants. Recently, very small devices designed to be implanted within small body structures such as the eye (Ahnood et al 2015;Ganesan 2014;Ganesan et al 2014;Garrett et al 2012;Hadjinicolaou et al 2012;Lichter et al 2015b;Maturana et al 2016;Nayagam et al 2015;Shivdasani 2013), or inside cortical blood vessels (Oxley et al 2016) have been developed. The recent surge in interest in electroceuticals for treatment of a range of disorders has led to a myriad of neuromodulation targets, such as the vagus nerve, for regulation of tumour necrosis factor (TNF) associated with autoimmune diseases of the digestive system (Crohn's disease) and rheumatoid arthritis (Martelli et al 2014;Tracey 2002).…”
Section: Introductionmentioning
confidence: 99%