INTRODUCTION
Long-term results comparing percutaneous transluminal angioplasty with or without stenting (PTA/S) and open surgical bypass for chronic limb-threatening ischemia (CLTI) in patients who have had no prior intervention are lacking.
METHODS
All patients undergoing a first-time lower extremity revascularization for CLTI by vascular surgeons at our institution from 2005 to 2014 were retrospectively reviewed. Outcomes included perioperative complications, wound healing, restenosis, primary patency, re-intervention, major amputation, RAS events (i.e., re-intervention, major amputation, or stenosis), and mortality. Outcomes were evaluated using chi-squared, Kaplan-Meier, and Cox regression analyses.
RESULTS
Of the 2,869 total lower extremity revascularizations performed between 2005 and 2014, 1,336 fit our criteria of a first-time lower extremity intervention for CLTI (668 bypass procedures and 668 PTA/S procedures). Bypass patients were younger (71 vs. 72 years, P=.02) and more often male (62% vs. 56%; P<.02). Total mean hospital length of stay (LOS) was significantly longer following a first-time bypass (10 vs. 8 days, P<.001), as were mean preoperative LOS (4 vs. 3 days, P<.01) and post-operative LOS (7 vs. 5 days, P<. 001). There was no difference in perioperative mortality (3% vs. 3%, P=.63). Surgical site infection occurred in 10% of bypass patients. Freedom from re-intervention was significantly higher in patients undergoing a first-time bypass procedure (62% vs. 52% at 3 years, P=.04), as was freedom from restenosis (61% vs. 45% at 3 years, P<.001). Complete wound healing at six-month follow-up was significantly better following an initial bypass (43% vs. 36%; P<.01). A Cox regression model of all patients showed that re-intervention was predicted by a first-time PTA/S (Hazard Ratio (HR) 1.6; 95% Confidence Interval [CI] 1.3–2.1) and both preoperative femoropopliteal TASC C and TASC D lesions (2.0[1.3–3.1] and 1.8 [1.3–2.7], respectively). Major amputation among all patients was predicted by an initial presentation of gangrene (2.5 [1.3–5.0]), dialysis dependence (1.9 [1.3–2.9]), diabetes (2.0 [1.1 –3.8]), and preoperative femoropopliteal TASC D lesions (2.1 [1.1 –4.0]), and was not predicted by procedure type.
CONCLUSIONS
In this retrospective analysis, bypass for the primary treatment of CLTI showed improved six-month wound healing, higher freedom from restenosis, improved patency rates, significantly fewer re-interventions, and higher survival than PTA/S within three years, but was associated with increased total hospital LOS and wound infection. Perioperative mortality and amputation rates were similar between procedure types.