Techniques used in orally disintegrating drug delivery system.

M, Wagh; Kothawade, Dilip Parag; Salunkhe, Kishor S.; Chavan, Nayana Vijay; Daga, Vandana R.

doi:10.5138/ijdd.2010.0975.0215.02018

Cited by 28 publications

(13 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The basic principle involves the addition of disintegrants and/or water soluble excipients and/or effervescent agents (Wagh et al, 2010). The choice and role of excipients are important in the formulation of FDTs (Nagar et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Application of general multilevel factorial design with formulation of fast disintegrating tablets containing croscaremellose sodium and Disintequick MCC-25

Solaiman

Suliman

Shinde

et al. 2016

International Journal of Pharmaceutics

View full text Add to dashboard Cite

A B S T R A C TDespite the popularity of orally fast disintegrating tablets (FDTs), their formulation can sometimes be challenging, producing tablets with either poor mechanical properties or high disintegration times. The aim of this research was to enhance the properties of FDTs produced by direct compression to have both sufficient hardness to withstand manual handling, and rapid disintegration time. General multilevel factorial design was applied to optimise and evaluate main and interaction effects of independent variables (i) disintegrant concentration, (ii) % filler (Disintequick MCC-25) to mannitol on the responses hardness, tensile strength and disintegration time. In this experiment mannitol was used as a diluent, Disintequick MCC-25 (to best of our knowledge there is no publication available yet for its use with FDTs) was termed in this study as a filler and croscaremellose sodium was used as the superdisintegrant. ) and friability of 2.2%; (ii) 7% or 10% w/w disintegrant with 33.33% w/w filler to mannitol, showing disintegration time of 84 s (for 7% disintegrant) and 107 s (for 10% disintegrant), hardness of 73.86 N (for 7% disintegrant) and 72.68 N (for 10% disintegrant) and friability of 1.44 (for 7% disintegrant) and 1.15% (for 10% disintegrant).

show abstract

Section: Introductionmentioning

confidence: 99%

Application of general multilevel factorial design with formulation of fast disintegrating tablets containing croscaremellose sodium and Disintequick MCC-25

Solaiman

Suliman

Shinde

et al. 2016

International Journal of Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Bonds are formed by compression or by using a binding agent. Granules, which have a small surface area, are more stable than powders having the same volume in humid air (Wagh et al, 2010).…”

Section: Methodsmentioning

confidence: 99%

Control of response time of early-stage concrete with accelerator using granulation processing

Lee¹,

Ryou²

2015

Magazine of Concrete Research

View full text Add to dashboard Cite

Although accelerators can be used to prevent early frost damage by developing the strength of concrete in cold weather, they do not lead to retention of workability because early hydration makes them react rapidly. In this study, granulation was used as a method to control the response time of the C 12 A 7 -based accelerator to retain the workability of fresh concrete. It was found that the workability of the granulated C 12 A 7 -based accelerator was retained for the operation time after mixing, and adequate strength was developed to prevent early frost damage.

show abstract

“…Various pharmaceutical techniques are used in the manufacture of ODTs, including: (1) freeze-drying or lyophilization [34], (2) spraydrying [35,36], (3) molding [37,38], (4) phase transition process [39], (5) melt-granulation [40][41][42], (6) sublimation [43,44] (7) mass extrusion [45], (8) cotton candy process [46,47], (9) nanonization [48], and (10) direct compression [40,[49][50][51][52][53]. Admittedly, direct compression is the most commonly used technique in the manufacture of ODTs, owing to its easy-implementation and cost-effectiveness [40,53]. These techniques are described below in detail.…”

Section: Formulation Processes For Developing Oral Disintegrating Tabmentioning

confidence: 99%

“…It involves using a blend of ingredients, which can provide rapid disintegration, as well as high physical integrity and stability. Sugar-based excipients as mannitol, sorbitol and lactose are commonly used as bulking agents, because of their high aqueous solubility and good taste-masking properties [40,[49][50][51][52][53].…”

Section: Direct Compressionmentioning

confidence: 99%

Insights Into Formulation Technologies and Novel Strategies for the Design of Orally Disintegrating Dosage Forms: A Comprehensive Industrial Review

Agiba¹,

Eldin²

2019

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Among the various routes of administration, the oral route remains the most convenient and commonly employed route for drug delivery. The oral conventional drug delivery systems have some drawbacks, such as possibility of gastrointestinal destruction of labile molecules, low absorption of macromolecules, slow onset of action, and unavoidable fluctuation in the concentration of drugs which can either lead to under-or over medication with concomitant adverse effects, especially for drugs with small therapeutic index. Therefore, it became essential to design novel oral drug delivery systems to achieve quick dissolution, absorption, rapid onset of action and reduction of drug dose. Among those novel drug delivery systems are oral disintegrating tablets (ODTs). The purpose of this review article is to report the recent advances in ODT systems with emphasis on their preparations, characterizations and applications. Also, it highlights future prospects and possible challenges in the development of an ideal ODT system.

show abstract

Techniques used in orally disintegrating drug delivery system.

Cited by 28 publications

References 16 publications

Application of general multilevel factorial design with formulation of fast disintegrating tablets containing croscaremellose sodium and Disintequick MCC-25

Application of general multilevel factorial design with formulation of fast disintegrating tablets containing croscaremellose sodium and Disintequick MCC-25

Control of response time of early-stage concrete with accelerator using granulation processing

Insights Into Formulation Technologies and Novel Strategies for the Design of Orally Disintegrating Dosage Forms: A Comprehensive Industrial Review

Contact Info

Product

Resources

About