Technische Grundlagen der OCT-Angiographie

Pp, Fang; Harmening, Wolf M.; Pl, Müller; Lindner, Moritz; Tu, Krohne; Fg, Holz

doi:10.1007/s00347-015-0184-6

Cited by 17 publications

(7 citation statements)

References 22 publications

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“…Im superfiziellen Plexus befinden sich die größten intraretinalen Gefäße, die mit ineinander verschlungenen Gefäßästen ein enges Kapillarnetz bilden. Im tiefen Plexus bilden dünnere Gefäße ein sehr dichtes komplexes Kapillarnetz, das aus horizontalen und radiären Verbindungen besteht [5,6]. Mit einer farbkodierten Retinagesamtaufnahme lassen sich die Informationen aller Segmentierungsschichten in einem dreidimensionalen Bild Zeiss Meditec, Inc., Dublin, USA) to create 6 × 6 mm and 3 × 3 mm volume scans of the area of non-perfusion in patients with RAO.…”

Section: Methodikunclassified

Neue Untersuchungsmöglichkeiten in der Beurteilung retinaler Arterienverschlüsse mittels OCT-Angiografie

Loidl

Enders

Werner

et al. 2017

Klin Monatsbl Augenheilkd

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Retinal artery occlusion (RAO) is the most common primary angiopathy of the retina. With an incidence of 0.01 - 0.15%, this it is a rather rare disease, but is associated with irreversible damage to the retina and a poor prognosis for visual acuity. Since the 1960s - when fluorescence angiography (FA) was developed -, there has been little change in diagnostic investigations. FA is still the standard procedure for the assessment of retinal artery occlusions. With the development of OCT angiography (OCT-A), new multimodal imaging procedures have become possible. We used Zeiss AngioPlex-OCT-A technology in combination with the CIRRUS HD-OCT 5000 (Carl Zeiss Meditec, Inc., Dublin, USA) to create 6 × 6 mm and 3 × 3 mm volume scans of the area of non-perfusion in patients with RAO. Qualitative OCT-A analysis was performed on retinal images segmented into the superficial and deep retinal capillary plexus. In addition to this, volumetric scans can be segmented to any specific depth of the retina. On the basis of 4 cases, we demonstrate that OCT-A can be used to evaluate RAO. We present typical OCT-A findings. OCT-A images allow the detection of non-perfused areas in patients with acute and chronic RAO. The zones of reduced vascular perfusion are differently distributed in the superficial and deep retinal capillary plexus. In both acute and chronic cases of RAO, OCT-A offers important information on retinal vascular perfusion. OCT-A can be used in the diagnosis and monitoring of acute and chronic cases of RAO. The advantages of OCT-A are that this technique is non-invasive and allows three dimensional microvascular visualisation within seconds. Although artefacts and the currently limited field of view can make it difficult to interpret OCT-A images reliably, these findings suggest that OCT-A may in future replace FA in the assessment of RAO in most patients.

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Section: Methodikunclassified

Neue Untersuchungsmöglichkeiten in der Beurteilung retinaler Arterienverschlüsse mittels OCT-Angiografie

Loidl

Enders

Werner

et al. 2017

Klin Monatsbl Augenheilkd

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“…Das Vorgehen ist wegen seiner Nichtinvasivität fluoreszenzbasierten Methoden vorzuziehen, kann aber prinzipbedingt keine vaskulodynamischen Ereignisse wie Pooling oder Leckagen darstellen. Die Kombination zwischen farbstoffassoziierter und en-face-reflexionsbildgestützter AO-Bildgebung (AO-SLO FA) ist heute, neben der kürzlich klinisch zugänglich gewordenen OCT-Angiografie [38], die vermutlich sensitivste Methode, mikrovaskuläre Veränderungen auf histologischem Niveau im lebenden Auge zu untersuchen [39]. Im Hinblick auf das wachsende Interesse an der Chorioidea im Rahmen der Pathogenese diverser Netzhauterkranungen konnten in Atrophiearealen von Chorioideremiepatienten chorioidale Gefäße in gleicher Auflösung sichtbar gemacht wer-den.…”

Section: Intraretinale Blutgefäßeunclassified

Adaptive Optiken – Möglichkeiten für die Diagnostik hereditärer Netzhauterkrankungen

Reiniger

Domdei

Pfau

et al. 2017

Klin Monatsbl Augenheilkd

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The use of adaptive optics in ophthalmoscopy is a breakthrough technological achievement. With AO ophthalmoscopes, the microscopic retinal structure can be visualised non-invasively and on a cellular level, allowing for cellular scale imaging of the retinal nerve fibre layer, the smallest retinal capillaries, rod and cone photoreceptors, and the retinal pigment epithelium mosaic in the living subject. Regarding the diagnostic evaluation of retinal diseases, the current research focuses on monogenetic retinal diseases, which - when better understood - may allow for conclusions to be drawn about other multifactorial diseases and their underlying mechanisms (model disease). For disease monitoring and current and future pharmacological intervention (e.g. gene therapy), they will help to better establish novel and reliable clinical endpoints. New AO imaging devices have just become commercially available, and the number of retinal pathologies visualised with AO is increasing. Recently, an AO-based microstimulation technique has been introduced, which offers the possibility to directly correlate retinal structure with visual function on a cellular level.

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“…Until now, there are only case reports concerning OCTA and one case series encompassing 3 patients in SC [15]. Therefore, the aim of this study is to describe these ndings in greater extent and compare them to known diagnostic tools, such as FA, ICGA, fundus auto uorescence (FAF), and enhanced depth imaging optical coherence tomography (EDI-OCT) [16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography Angiography (OCTA) findings in Serpiginous Choroiditis

Macedo

Pohlmann

Lenglinger

et al. 2020

Preprint

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Abstract Background. To describe changes in the retina/choroid in patients with Serpiginous Choroiditis (SC) by Optical Coherence Tomography Angiography (OCTA) in a multimodal imaging approach. Methods. Prospective, monocentric study of 24 eyes of 12 consenting patients diagnosed with SC, who underwent OCTA, which was analyzed and compared to other methods such as enhanced depth imaging-OCT, fluorescein angiography, indocyanine green angiography, and fundus autofluorescence. Results. The study group consisted of 9 patients with peripapillary SC, 1 macular SC, and 2 atypical cases. All eyes presented an inactive SC confirmed by standard imaging. OCTA demonstrated the lesions tridimensionally in great detail. There was no difference in the angioarchitecture among the 3 forms of SC. A loss of the choriocapillaris/retinal pigment epithelium left a “window-defect”, where the vessels of larger caliber of the choroid became recognizable and their appearance inverted (“white-on-black”). A relationship between the presence of segmentation errors (SE) in the slabs and low visual acuity was established with a one-way ANOVA. Conclusions. OCTA was able to non-invasively assess vascular lesions of the choroid/retina in patients with SC with a high degree of correlation to other diagnostic modalities. Consequent long-term assessments could lead to a better understanding of disease progression.

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Technische Grundlagen der OCT-Angiographie

Cited by 17 publications

References 22 publications

Neue Untersuchungsmöglichkeiten in der Beurteilung retinaler Arterienverschlüsse mittels OCT-Angiografie

Neue Untersuchungsmöglichkeiten in der Beurteilung retinaler Arterienverschlüsse mittels OCT-Angiografie

Adaptive Optiken – Möglichkeiten für die Diagnostik hereditärer Netzhauterkrankungen

Optical Coherence Tomography Angiography (OCTA) findings in Serpiginous Choroiditis

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