Technische Systeme für den Herzersatz und die Herzunterstützung

An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes

“…A different approach is usually applied in bearingless pump systems, which are used in biotechnology (Schöb 2002 ) as well as in medicine as left ventricular assist devices for the treatment of heart disorders (Schöb and Loree 2008 ) or to maintain blood circulation during heart transplants (Sung et al 2015 ). Bearingless pump systems are characterized by low shear stresses (Blaschczok et al 2013 ; Dittler et al 2014 ; Schirmer and Eibl 2018 ), which has led to their use in the operation of bioreactors (Reichert et al 2009 ; Schirmer et al 2018 ) and mixing systems in the pharmaceutical industry (Sartorius Stedim Biotech GmbH 2019 ).…”

“…A permanent magnet ring can be used to stabilize both rotations along the x - and z -axes and translation along the y -axis. Centering the rotor on the x - and z -axis origin is achieved by two active magnetic bearings, and the last degree of freedom, rotation around the y -axis, is actively controlled by the motor drive (Schöb and Loree 2008 ; Nussbaumer et al 2011 ). To stabilize the radial position of the rotor at high speeds, the magnetic field is adjusted 10,000 times per second (Levitronix GmbH 2020 ).…”