Technischer Erfolg, Resektionsstatus sowie prozedurale Komplikationensrate der endoskopischen Vollwandresektion mittels „Full Thickness Resection Device“ (FTRD) – Ergebnisse einer gepoolten Analyse aus verschiedener Kliniken

Krutzenbichler, I; Dollhopf, Markus; Lewerenz, Björn; Lillje, T; Fuchs, Martin; Herrmann, Simon; Vitali, Francesco; Räth, Timo; Kaiser, Christoph; Eigler, Andreas; Diepolder, Helmut M.; Schepp, Wolfgang; Gundling, Felix

doi:10.1055/s-0039-1695531

Cited by 1 publication

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“…There was no indication of heterogeneity ( I 2 = 0 %, p = 0.99); however, the study by Krutzenbichler et al. 13 was identified as influential study. Leaving this study out led to a pooled estimate of 96.3 % (95 % CI: 94.7–97.4).…”

Section: Resultsmentioning

confidence: 95%

“…The main reasons for not reaching the target lesion were unsuccessful passage of the sigma (n = 11) and difficulties advancing the endoscope with mounted FTRD to the target lesion (n = 11), while the cause was not further specified in the remaining cases (n = 5). There was no indication of heterogeneity (I 2 = 0 %, p = 0.99); however, the study by Krutzenbichler et al [13] was identified as influential study. Leaving this study out led to a pooled estimate of 96.3 % (95 % CI: 94.7-97.4).…”

Section: Effectiveness Of Ftrd In the Colonmentioning

confidence: 95%

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Systematic review and meta-analysis on effectiveness and safety of the full-thickness resection device (FTRD) in the colon

2021

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Background Endoscopic full-thickness resection (EFTR) has expanded the possibilities of endoscopic resection. The full-thickness resection device (FTRD, Ovesco Endoscopy, Tübingen, Germany) combines a clip-based defect closure and snare resection in a single device. Methods Systematic review and meta-analysis on effectiveness and safety of the FTRD in the colon. Results A total of 26 studies (12 published as full-text articles and 14 conference papers) with 1538 FTRD procedures were included. The pooled estimate for reaching the target lesion was 96.1 % (95 % confidence interval [95 % CI]: 94.6–97.1) and 90.0 % (95 % CI: 87.0–92.3) for technically successful resection. Pooled estimate of histologically complete resection was 77.8 % (95 % CI: 74.7–80.6). Adverse events occurred at a pooled estimate rate of 8.0 % (95 % CI: 5.8–10.4). Pooled estimates for bleeding and perforation were 1.5 % (95 % CI: 0.3–3.3) and 0.3 % (95 % CI: 0.0–0.9), respectively. The rate for need of emergency surgery after FTRD was 1.0 % (95 % CI: 0.4–1.8). Conclusion The use of the FTRD in the colon shows very high rates of technical success and complete resection (R0) as well as a low risk of adverse events. Emergency surgery after colonic FTRD resection is necessary in single cases only.

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Section: Resultsmentioning

confidence: 95%

Section: Effectiveness Of Ftrd In the Colonmentioning

confidence: 95%