This feasibility study explores the viability of solar PV-powered Reverse Osmosis (RO) desalination in five locations in Visakhapatnam, India. The assessment integrates technical, economic, environmental, social, and political considerations using Multi-Criteria Decision Analysis (MCDA) with Fuzzy Technique for Order of Preference by Similarity to Ideal Solution (Fuzzy TOPSIS) and Fuzzy Analytic Hierarchy Process (Fuzzy AHP) methods to handle uncertainties in decision-making. The study evaluates the technical feasibility of the integration, conducts economic analysis, examines environmental impacts, investigates social benefits, and challenges, and analyzes the political landscape. The former emphasizes the significance of understanding challenges and potential solutions associated with RO desalination, aiming for sustainable development aligned with local and global goals. Yarada and Bheemili were the most suitable locations selected based on Fuzzy TOPSIS and Fuzzy AHP, respectively. The study also highlighted the need for public awareness and government support for desalination projects.