In this study, four new indirect heat pump assisted mechanical vapor compression humidification-dehumidification (HDH) systems are proposed and their superiorities over the reference system are demonstrated from thermodynamics and thermoeconomics viewpoints. The proposed models are configured based on an HDH unit and a simple cascade heat pump, an HDH unit and a heat pump with an ejector, an HDH unit and a cascade heat pump with an ejector, and an HDH unit and a vapor injection heat pump. Although employing a heat pump with cascade and ejector configurations improved gain-output-ratio (GOR) and specific power consumption (SPC) values in comparison with the base system, the performance metrics of such layouts are still inferior to those of the HDH unit coupled with the vapor injection heat pump. It is found that the desalination unit with vapor injection mechanism has the highest GOR and the lowest SPC values of 9.22 and 71.29 kWh/m 3 , respectively, under constant electrical power of 31.26 kW. Overall, proposal of the cascade heat pump, heat pump with an ejector, cascade heat pump with an