Techno-Economic Modelling and Assessment of Cultivated Meat:  Impact of Production Bioreactor Scale

Negulescu, Patrick G.; Risner, Derrick; Spang, Edward S.; Sumner, Daniel A.; Block, David; Nandi, Somen; McDonald, Karen A.

doi:10.31224/2414

Cited by 3 publications

(2 citation statements)

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“…Cultivated meat in particular faces challenges to significantly scale-up production, such as bioreactor and media costs. Consumer acceptance levels will also impact market share (Bryant and Barnett 2018;Humbird 2021;Negulescu et al 2022). 4 Low end of the Jeffries forecast (Powell et al 2019) assumes low overall growth in meat consumption (2 per cent annually from 2018-2040) due to health concerns, weak consumer confidence in novel alternatives due to product recalls, production techniques constrained by regulators, and no enactment of a meat tax.…”

Section: 2mentioning

confidence: 99%

Frontiers 2023. What’s Cooking? An assessment of the potential impacts of selected novel alternatives to conventional animal products

2023

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The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory or city or area or its authorities, or concerning the delimitation of its frontiers or boundaries.Mention of a commercial company or product in this document does not imply endorsement by the United Nations Environment Programme or the authors. The use of information from this document for publicity or advertising is not permitted. Trademark names and symbols are used in an editorial fashion with no intention on infringement of trademark or copyright laws.The views expressed in this publication are those of the authors and do not necessarily reflect the views of the United Nations Environment Programme. We regret any errors or omissions that may have been unwittingly made.

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Section: 2mentioning

confidence: 99%

Frontiers 2023. What’s Cooking? An assessment of the potential impacts of selected novel alternatives to conventional animal products

2023

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“…Specific challenges to media development for cultured meat are a traditional dependence on animal-derived components such as fetal bovine serum (FBS), or else the prohibitively expensive cost of serum-free media (SFM) formulations. As media are projected to account for over 90% of the production costs of cultured meat 6 , lowering the cost of appropriate animal component-free media is essential for achieving price parity with conventional meats.…”

Section: Introductionmentioning

confidence: 99%

A Beefy-R culture medium: replacing albumin with rapeseed protein isolates

Stout

Rittenberg

Shub

et al. 2022

Preprint

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The development of cost-effective serum-free media is essential for the economic viability of cultured meat. A key challenge facing this goal is high-cost recombinant albumin that is necessary in some available serum-free media formulations. As such, there is substantial interest in finding albumin alternatives which are low-cost, effective, scalable, sustainable, and suitable for food applications. Recently, a serum-free medium termed Beefy-9 was developed for bovine satellite cells (BSCs), which relied on recombinant albumin as a key component to replace fetal bovine serum. Here we alter Beefy-9 by replacing albumin with rapeseed protein isolate, a bulk-protein solution obtained from agricultural waste-streams through simple isoelectric protein precipitation. This new medium, termed Beefy-R, improves BSC growth compared with Beefy-9 while maintaining cell phenotype and myogenicity. These results offer an effective, low-cost, and sustainable alternative to albumin for serum-free culture of muscle stem cells, thereby addressing a key hurdle facing cultured meat production.

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Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology

Bomkamp¹,

Musgrove

Marques

et al. 2022

Mar Biotechnol

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Cultivated meat, also known as cultured or cell-based meat, is meat produced directly from cultured animal cells rather than from a whole animal. Cultivated meat and seafood have been proposed as a means of mitigating the substantial harms associated with current production methods, including damage to the environment, antibiotic resistance, food security challenges, poor animal welfare, and—in the case of seafood—overfishing and ecological damage associated with fishing and aquaculture. Because biomedical tissue engineering research, from which cultivated meat draws a great deal of inspiration, has thus far been conducted almost exclusively in mammals, cultivated seafood suffers from a lack of established protocols for producing complex tissues in vitro. At the same time, fish such as the zebrafish Danio rerio have been widely used as model organisms in developmental biology. Therefore, many of the mechanisms and signaling pathways involved in the formation of muscle, fat, and other relevant tissue are relatively well understood for this species. The same processes are understood to a lesser degree in aquatic invertebrates. This review discusses the differentiation and maturation of meat-relevant cell types in aquatic species and makes recommendations for future research aimed at recapitulating these processes to produce cultivated fish and shellfish.

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Techno-Economic Modelling and Assessment of Cultivated Meat: Impact of Production Bioreactor Scale

Cited by 3 publications

References 0 publications

Frontiers 2023. What’s Cooking? An assessment of the potential impacts of selected novel alternatives to conventional animal products

Frontiers 2023. What’s Cooking? An assessment of the potential impacts of selected novel alternatives to conventional animal products

A Beefy-R culture medium: replacing albumin with rapeseed protein isolates

Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology

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