This work presents a techno-economic analysis of a novel gasification system, chemical looping gasification (CLG), used as the primary gasification process for biofuel production through Fischer−Tropsch synthesis (FTS). Two different gas cleaning process configurations, cold-gas cleanup and hot-gas cleanup process trains, are explored, along with off-gas utilization possibilities, to study their influence on the process economics of an integrated CLG−FT process plant. Off-gas recirculation to increase Fischer−Tropsch (FT) crude production has a significant influence on reducing the levelized production costs for FT crude. The results indicate that the specific production cost estimated for a CLG−FT plant with a hot-gas cleanup train is roughly 10% lower than the case with a cold-gas cleanup train, while the total plant costs remain relatively the same for all plant configurations. In addition to this, the former has a considerably higher overall system energy efficiency of 63%, roughly 18% more than the latter, considering the co-production of FT crude, district heating, and electricity. The specific investment costs range from 1.5 to 1.7 M€ 2018 /MW LHV , and the specific FT crude production cost ranges from 120 to 147 € 2018 /MWh FT . Roughly 60% of total carbon fed to the process is captured, enabling net-negative CO 2 emissions. A CO 2 price for negative emissions would significantly reduce the specific fuel production costs and would, hence, be competitive with fossil-based liquid fuels.