Technobiology Paradigm in Nanomedicine: Treating Cancer with MagnetoElectric Nanoparticles

Permeation Challenges of Drugs for Treatment of Neurological Tuberculosis and HIV and the Application of Magneto-Electric Nanoparticle Drug Delivery Systems

“…MENs are comprised of a lattice crystal structure with a magnetostrictive cobalt ferrite (CoFe 2 O 4 ) core surrounded by a barium titanate (BaTiO 3 ) piezoelectric shell. The tetragonal crystal structure of the BaTiO 3 shell and the cubic structure of the CoFe 2 O 4 core has been shown using X-ray diffraction (XRD) [ 30 ]. Microscopy images of MENs show an irregular-sphere-like morphology [ 98 , 99 ].…”

“…Microscopy images of MENs show an irregular-sphere-like morphology [98,99]. MENs offer advantages in that they are able/show potential to (i) achieve targeting driven by an external magnetic force, (ii) provide on-demand externally controlled drug release and (iii) provide image-guided precision drug delivery [30]. These properties are advantageous towards drug delivery in the CNS for TB and HIV.…”

“…Nanoelectroporation is the use of focused electric pulse to porate the cell membrane to form a nanopore and also provides electrophoretic mobility of charged drug/gene molecules and/or NPs to move into the cell. Similar to other magnetic NPs, MENs have a nonzero saturation magnetization that could enable them to be guided throughout the body by the application of magnetic field gradients [ 29 , 30 ]. Subsequently, these NPs could be localized using traditional image-guided magnetic processes such as MRI and magnetic particle imaging [ 29 ] to facilitate drug delivery across the CNS.…”