In order to study the diffusion law of grouting slurry in sand areas, the grouting of cement slurry in sand was analyzed by the indoor grouting test under different water-cement ratios, grouting pressures, grouting amounts, and soil qualities, and the law of the post-grouting slurry is obtained. The results show that the grouting method is affected by the grouting pressure, water-cement ratio, grouting amount, and soil quality. Under the same grouting pressure, the diffusion modes of different water-cement ratio grouts in sands with different permeability coefficients, which are mainly manifested as osmotic diffusion, are basically the same; under the same water-cement ratio, when the grouting pressure is relatively small, the diffusion of modes of slurry is mainly osmotic in sand. The diffusion radius of cement slurry in sand has a good power function relationship with grouting pressure, water-cement ratio, permeability coefficient, and grouting amount. And, the empirical function model of slurry diffusion radius is proposed by regression analysis. The research results provide a certain theoretical and experimental reference for post-grouting in sandy areas.