Objectives. As social creatures, we monitor our relative rank and/or status with others via social comparisons. Whilst research has identified perceptions of inferiority or 'low rank' relative to others is a robust predictor of depressive, anxious, and stress symptomology, to date individual differences have been ignored. We wish to provide empirical evidence to outline how differences across personality traits may interact with social rank variables to buffer or predispose towards depressive symptomology.Methods. Across three independent samples (N = 595), we replicated a social rank model of mental health, and with our third sample (N = 200), we sought to investigate attenuating roles for neuroticism versus compassion with multiple moderated regression models.Results. Neuroticism predicted greater levels of rank-associated depression, and compassion failed to function as a protective factor for rank-associated depression. However, a closer inspection of the original Big-5 factor structure positions this scale as a measure of 'interpersonal submissiveness' or 'conflict appeasement' rather than genuine compassion.Conclusions. Whilst it is necessary to delineate the conditions where compassion is appropriate and able to lead to positive mental health outcomes, we argue this cannot be addressed with the Big-5 measure of trait compassion. We call for future work to consider valid and reliable measures for compassion, such as the self-compassion scale, submissive compassion scale, and fears of compassion scale, to more fully address how compassion may protect against both rank-based comparisons and severity of depression.