The article examines the effect of mineral fertilizers on the growth, development and yield of grape varieties with large clusters. The transition periods of phenological phases, productivity indicators, chemical composition of grape bunch cluster weight and juice, influence of mineral fertilizers on the mechanical composition of grape bunch and cluster were determined. In the study of the effects of different rates of mineral fertilizers, the transition periods of phenological phases, the mechanical and chemical composition of grape bunch clusters were analyzed mathematically and statistically, it was proved that the highest result was given when N160 P120 K40 kg/ha was given. When mineral fertilizer N160 P120 K40 kg/ha is applied, flowering and ripening periods start 3 and 6 days earlier in varieties, sugar content is 1.6% high, acidity is 0.5 g/l, shingles is 1.5%, and flesh and juice is 1.8 % is high, 2.8% is less in the seed and it is found that the rudiment seed does not differ significantly.