Technological issues for the development of more efficient calcium phosphate bone cements: A critical assessment

Bohner, Marc; Gbureck, Uwe; Barralet, Jake E.

doi:10.1016/j.biomaterials.2005.03.049

Cited by 399 publications

(356 citation statements)

References 46 publications

Supporting

Mentioning

345

Contrasting

Unclassified

Order By: Relevance

“…Proper opacification is essential for fluoroscopic monitoring of cement injection to prevent extravasation and, thus, the potential complication of pulmonary embolism [59,60]. The addition of nanoparticle radiopacifiers, such as barium sulfate and zirconium dioxide, improve osteoblast adhesion than plain PMMA bone cement.…”

Section: Radioopacificationmentioning

confidence: 99%

“…A theoretical model was proposed by Bohner et al to analyze the distribution of a PMMA cement after its injection into a porous structure [28]. The calculations were based on two rheological laws: the law of Hagen-Poiseuille describing the flow in a cylindrical tube and the law of Darcy describing the fluid through a porous media by assuming the path of least resistance is cylindrical and the cement can only extravasate if it pushes the marrow out of the way when the cement is injected into an osteoporotic vertebral body.…”

Section: Pmma Cement Based Mathematical Modelmentioning

confidence: 99%

See 1 more Smart Citation

A Review of PMMA Bone Cement and Intra-Cardiac Embolism

Shridhar¹,

Chen²,

Khalil³

et al. 2016

Preprint

View full text Add to dashboard Cite

Percutaneous vertebroplasty procedure is of major importance, given the significant increasing aging population and higher number of orthopedic procedures related to vertebral compression fractures. Vertebroplasty is a complex technique involving injection of polymethylmethacrylate (PMMA) into the compressed vertebral body for mechanical stabilization of the fracture. Our understanding and ability to modify these mechanisms through alterations in cement material is rapidly evolving. However, the rate of cardiac complications secondary to PMMA injection and subsequent cement leakage has increased with time. The following review considers the main features of PMMA bone cement on the heart, and the extent of influence of materials on cardiac embolism. Clinically, cement leakage results in life-threatening cardiac injury. The convolution of this outcome through an appropriate balance of complex material properties is highlighted via clinical case report.

show abstract

Section: Radioopacificationmentioning

confidence: 99%

Section: Pmma Cement Based Mathematical Modelmentioning

confidence: 99%

A Review of PMMA Bone Cement and Intra-Cardiac Embolism

Shridhar¹,

Chen²,

Khalil³

et al. 2016

Preprint

View full text Add to dashboard Cite

show abstract

“…Though there are numerous scientific studies on CPCs, there is still an ongoing need for better understanding of the physical, chemical, and biological properties of these implant materials [3]. Calcium carbonate cements are also a subject of intensive studies [4].…”

Section: Introductionmentioning

confidence: 99%

Do novel cement-type biomaterials reveal ion reactivity that affects cell viability in vitro?

et al. 2013

View full text Add to dashboard Cite

Calcium phosphate bioceramics have been studied as bone filler materials for years and have become a component of many commercial products. It is widely known that surface-reactive biomaterials may cause changes in the concentration of crucial ions in the surrounding environment, thereby affecting cell metabolism and viability. The aim of this study was to produce five cement-type biomaterials and characterize their phase composition using X-ray diffraction method, and porosity and pore size distribution using mercury intrusion porosimeter. We then evaluated ion interactions of the novel biomaterials with the surrounding environment (culture medium). A commercially available bone substitute, HydroSet™ (Stryker®), was used as a reference. MTT and NRU cytotoxicity tests were performed to assess the effect of changes in the concentration of crucial ions (calcium, magnesium, phosphate) on osteoblast metabolism and viability in vitro. Our study clearly indicated that various biomaterials demonstrated different ion reactivity and consequently may cause changes in ion concentration in the local environment. Critically low or high values of calcium, magnesium, and phosphate concentrations in the medium exerted cytotoxic effects on the cultured cells. Moreover, we discovered that the chemical composition of the culture medium had a substantial influence on ion interactions with biomaterials.

show abstract

“…Although the biological performance of CaPs is well proven and they possess excellent biocompatibility and osteoconductive properties, clinical results continue to be inferior to those seen with autograft or allograft. Therefore, development of new or modified synthetic bone substitutes continues apace (Bohner et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Designs from the deep: Marine organisms for bone tissue engineering

Clarke

Walsh

Maggs

et al. 2011

Biotechnology Advances

View full text Add to dashboard Cite

Current strategies for bone repair have accepted limitations and the search for synthetic graft materials or for scaffolds that will support ex vivo bone tissue engineering continues. Biomimetic strategies have led to the investigation of naturally occurring porous structures as templates for bone growth. The marine environment is rich in mineralizing organisms with porous structures, some of which are currently being used as bone graft materials and others that are in early stages of development. This review describes the current evidence available for these organisms, considers the relative promise of each and suggests potential future directions.

show abstract

Technological issues for the development of more efficient calcium phosphate bone cements: A critical assessment

Cited by 399 publications

References 46 publications

A Review of PMMA Bone Cement and Intra-Cardiac Embolism

A Review of PMMA Bone Cement and Intra-Cardiac Embolism

Do novel cement-type biomaterials reveal ion reactivity that affects cell viability in vitro?

Designs from the deep: Marine organisms for bone tissue engineering

Contact Info

Product

Resources

About