Background: The aging global population presents significant challenges for healthcare systems. Technology-assisted interventions have emerged as promising tools to enhance independence and well-being among elderly individuals. Objective: The aim of this study was to evaluate the effectiveness of technology-assisted interventions in promoting independence among elderly patients and identify key barriers and facilitators to their implementation. Methods: A systematic review was conducted following PRISMA guidelines. Searches were performed in PubMed, IEEE Xplore, ACM Digital Library, Cochrane Library, and Scopus. Studies evaluating technology-assisted interventions for promoting independence in elderly patients were included. Data were synthesized through narrative and thematic analysis. Results: Fourteen studies met inclusion criteria. Technology-assisted interventions demonstrated positive impacts on physical and cognitive functioning, health management, quality of life, and technological engagement among elderly patients. Improvements were observed in areas such as mobility, chronic disease management, mental health, and daily living activities. High usability and adherence rates were reported for well-designed interventions. However, challenges in user-centered design, personalization, and integration with existing healthcare systems were identified. Conclusions: Technology-assisted interventions show promise in promoting independence among elderly patients. Future research should focus on addressing identified challenges and conducting larger, long-term studies to confirm effectiveness and sustainability.