A range of innovative computer-based interventions for psychiatric disorders have been developed, and are promising for drug use disorders, due to reduced cost and greater availability compared to traditional treatment. Electronic searches were conducted from 1966 to November 19, 2009 using MEDLINE, Psychlit, and EMBASE. 468 non-duplicate records were identified. Two reviewers classified abstracts for study inclusion, resulting in 12 studies of moderate quality. Eleven studies were pilot or full-scale trials compared to a control condition. Interventions showed high acceptability despite substantial variation in type and amount of treatment. Compared to treatment-as-usual, computer-based interventions led to less substance use as well as higher motivation to change, better retention, and greater knowledge of presented information. Computerbased interventions for drug use disorders have the potential to dramatically expand and alter the landscape of treatment. Evaluation of internet and phone-based delivery that allow for treatmenton-demand in patients' own environment is needed.Automated computer-based treatment is a promising vehicle for providing behaviorallybased interventions for drug use disorders. These systems offer a number of potential advantages, including low cost, greater accessibility and 24-hour availability, opportunity for more frequent and/or longer therapeutic contact, greater confidentiality, increased flexibility and convenience, and increased opportunities for practicing skills (Budman, 2000;Marks, Shaw, & Parkin, 1998;Nadelson, 1987). Such systems may even be preferred by some clients who dislike therapy or have concerns about confidentiality, and may be particularly useful in rural or remote settings, where access to psychotherapy for substance use disorders may be limited and accompanied by increased stigma (Connors, Tonnigan, & Miller, 2001;Hall & Huber, 2000). Automated computer-based systems also offer more consistent and precise delivery of interventions across patients. This standardization can be of value therapeutically and, from a scientific perspective, may permit a detailed examination of active components. The current systematic review evaluated computer-based interventions for drug use disorders. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. , 2008). This may be due to differences in length of respective computer-based interventions since interventions in tobacco studies (e.g., 10-12 weeks) tend to be longer than those in alcohol studies (e.g., short assessment with personalized feedback). Moreover, within computer-based smok...