This article reports a comparative study of two artificial neural network structures and associated variants used to describe and predict the behavior of 2 × 200 μm2 GaN high electron mobility transistors (HEMTs), utilizing radiofrequency characterization. Two architectures namely multilayer perceptron and cascade feedforward, have been investigated in this work to develop the behavioral model. A study is conducted utilizing the two architectures, all trained using Levenberg‐Marquardt, in terms of accuracy, convergence rate, and generalization capability to develop the behavioral model of GaN HEMT. However, to ensure the robustness of the model, accuracy, convergence rate, time elapsed, and generalization capability of the proposed model is also tested under couple of training algorithms, activation functions, number of hidden layers and neuron embedded inside it, methods for initialization of weights and bias and certain other vital parameters playing vital role in influencing the model accuracy and effectiveness. An excellent agreement found between measured S‐parameters and the proposed model proves the effectiveness of the proposed approach and excellent prediction ability for a sweeping multibias set and broad frequency range of 1 to 18 GHz. Moreover, a very good generalization capability is also recorded under variation of crucial parameters of GaN HEMT‐based neural model.