Technology optimization of chitosan production from Aspergillus niger biomass and its functional activities

Abdel-Gawad, Khayria M.; Hifney, Awatief F.; Fawzy, Mustafa A.; Gomaa, Mohamed

doi:10.1016/j.foodhyd.2016.10.001

Cited by 98 publications

(50 citation statements)

References 22 publications

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“…Under optimum conditions, the optimised DDA and MM of chitosan were 90.58 ± 2.04% and 124.25 ± 14.36 kDa, respectively. The results obtained through subsequent experiments are in agreement with the predicted values from optimisation analysis using desirability functions indicating the adequacy of the developed quadratic models (Abdel‐Gawad et al ., ). Therefore, the superiority of established degradation method is low cost, and more stable and takes less time as compared to the conventional chemical degradation method.…”

Section: Resultsmentioning

confidence: 97%

Microwave‐assisted degradation of chitosan with hydrogen peroxide treatment using Box‐Behnken design for enhanced antibacterial activity

Zhang

Chen

et al. 2017

Int J of Food Sci Tech

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SummaryLow molecular mass (MM) chitosan with high degree of deacetylation (DDA) has excellent bioactivity including antioxidant, antibacterial and encapsulation properties. In this work, to reduce the MM of chitosan, microwave-assisted heating treatment (MAHT) conditions were investigated using three factors at three levels Box-Behnken design (BBD). Microwave heating (MH) time, H 2 O 2 concentration and solid-toliquid ratio significantly affected the DDA and MM of chitosan. The antibacterial activities of chitosan before and after degradation were investigated based on minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The results showed that a second-order polynomial equation fitted the observed values using multiple regression analysis and had a high coefficient of determination (R 2 = 0.9591 and 0.9161 for the DDA and MM of chitosan, respectively). An optimisation study was performed using Derringer's desirability function methodology, and the optimal conditions were 80-s MH time, 1.5% H 2 O 2 concentration and 1:40 solid-to-liquid ratio. The MIC and MBC of chitosan before and after degradation against Escherichia coli and Salmonella typhimurium were 0.031 and 0.063 mg mL À1 , and 0.25 and 0.125 mg mL À1 , respectively. The optimised DDA and MM of chitosan were 90.58 AE 2.04% and 124.25 AE 14.36 kDa, respectively, which significantly reduces the use of oxidant reagent.

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Section: Resultsmentioning

confidence: 97%

Microwave‐assisted degradation of chitosan with hydrogen peroxide treatment using Box‐Behnken design for enhanced antibacterial activity

Zhang

Chen

et al. 2017

Int J of Food Sci Tech

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“…For example, fungal chitosan from shiitake stipes has shown antioxidant activity, hydroxyl radical scavenging capacity and ferrous ion chelating ability . Recently, the antioxidant potential of chitosan from A. niger exhibited good results for hydroxyl radical scavenging activity (82.4%) and ferrous ion chelating ability (87.2%) . Similarly, Zimoch‐Korzycka et al .…”

Section: Applications Of Fungal Chitin Chitosan and Chitin/chitosan–mentioning

confidence: 99%

Chitinous polymers: extraction from fungal sources, characterization and processing towards value‐added applications

Araújo

Ferreira

Torres

et al. 2020

J of Chemical Tech & Biotech

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Chitin, chitosan and their complexes with β‐glucan (chitin–glucan complex, CGC, and chitosan–glucan complex, ChGC) are value‐added polysaccharides extracted from the cell‐walls of many fungi. Commercial chitin and its deacetylated form, chitosan, are currently obtained from marine waste material, mostly animal sources (crustaceans and marine invertebrates), through harsh chemical procedures that have low reproducibility due to the variability of the composition of the sources and their seasonal character. These disadvantages are overcome by using fungi as sources of chitinous polymers. The extraction of chitin/chitosan from fungi cell‐walls has the great advantage of yielding products with stable composition and properties, using simpler procedures, with the added benefit of also generating CGC and ChGC, two copolymers that combine the proven properties of chitin/chitosan with those of β‐glucans. Over the last decades, fungal chitinous polymers have been the focus of extensive research that included optimization of the cultivation conditions of a wide range of species and the development of optimized extraction, purification and characterization techniques, as well as the demonstration of the biopolymers' biological properties, which include immunomodulatory, anticancer, antioxidant and antimicrobial activity. Given these properties, several attempts were made to develop applications for them in areas ranging from biomedicine and pharmaceuticals to food and agriculture. Despite their wide range of proven functional properties that include the ability to form different polymeric structures, as well as biological activity, fungal chitinous biopolymers are still underexplored. Nevertheless, these biopolymers hold great potential for development into valuable products or applications that are surely worth further investigation. © 2019 Society of Chemical Industry

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“…Bioplastic formulations were recently tested for seed coating of agronomic species. These coatings, which contain spores of growth promoters such as T. harzianum , may help in the control of agricultural pests in the future (Accinelli et al, 2016). Bioplastics also have the potential to lead to the rise, within civil construction, of materials that have low incorporated energy, contributing to energy efficiency (Ivanov and Stabnikov, 2016).…”

Section: Materials Technological Microbiologymentioning

confidence: 99%

“…Chitosan can be easily recovered from the cell wall of fungi such as A. niger, Rhizopus oryzae, Cunninghamella elegans , and Mucor indicus , among others (Pochanavanich and Suntornsuk, 2002; Franco et al, 2004; Ruholahi et al, 2016; Abdel-Gawad et al, 2017). Specific interactions with extracellular matrix components allow the use of chitosan in the field of tissue engineering to repair skin, bone, and cartilage (Khor and Lim, 2003).…”

Section: Materials Technological Microbiologymentioning

confidence: 99%

Technological Microbiology: Development and Applications

Vitorino

Bessa

2017

Front. Microbiol.

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Over thousands of years, modernization could be predicted for the use of microorganisms in the production of foods and beverages. However, the current accelerated pace of new food production is due to the rapid incorporation of biotechnological techniques that allow the rapid identification of new molecules and microorganisms or even the genetic improvement of known species. At no other time in history have microorganisms been so present in areas such as agriculture and medicine, except as recognized villains. Currently, however, beneficial microorganisms such as plant growth promoters and phytopathogen controllers are required by various agricultural crops, and many species are being used as biofactories of important pharmacological molecules. The use of biofactories does not end there: microorganisms have been explored for the synthesis of diverse chemicals, fuel molecules, and industrial polymers, and strains environmentally important due to their biodecomposing or biosorption capacity have gained interest in research laboratories and in industrial activities. We call this new microbiology Technological Microbiology, and we believe that complex techniques, such as heterologous expression and metabolic engineering, can be increasingly incorporated into this applied science, allowing the generation of new and improved products and services.

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Technology optimization of chitosan production from Aspergillus niger biomass and its functional activities

Cited by 98 publications

References 22 publications

Microwave‐assisted degradation of chitosan with hydrogen peroxide treatment using Box‐Behnken design for enhanced antibacterial activity

Microwave‐assisted degradation of chitosan with hydrogen peroxide treatment using Box‐Behnken design for enhanced antibacterial activity

Chitinous polymers: extraction from fungal sources, characterization and processing towards value‐added applications

Technological Microbiology: Development and Applications

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