Quality is the lifeline for the survival and development of enterprises. With the continuous infiltration of sustainable development green concepts and the occurrence of quality and safety incidents, the green quality crisis of enterprises is gradually being valued by enterprises. The green quality immune system of enterprises is an important defense line when facing crises, which includes three immune methods: supervision, defense, and memory. This article analyzes the green quality immune system of enterprises before, during, and after the crisis, revealing the formation mechanism of the resilience of the "specialized, refined, and new" enterprise green quality immune system, making the "specialized, refined, and new" enterprise green quality immune system more resilient.