Located at the outer edge of the northeastern Tibetan Plateau, the Qilian Shan has long been considered to be the key area to address the issue of how the Tibetan Plateau generates its high topography. However, in spite of the fruitful achievements on the growth pattern and subtle crustal structures of the Qilian Shan, what we know about the regional topography evolution and its relationship with the deep structures are still lacking. In this study, the landscape features of the eastern Qilian Shan and the probable drainage evolution history of the Lenglong Ling, located within the central part of the eastern Qilian Shan, are investigated, based on the multiple geomorphic analyses (i.e., HI and steepness distributions, and the Gilbert and χ metrics). The topographic results show that high HI and steepness values distribute mainly in areas controlled by active faults (i.e., the mountain areas). In addition, the Gilbert and χ metrics suggest that the main Lenglong Ling divide is stable. According to the drainage divide stability criteria, we suggest that the presence of the uplift rate gradient in the eastern Qilian Shan (i.e., with higher uplift in the Lenglong Ling area), which is suggested by the topographic results, has driven the main divide to migrate southward and is now “holding” the divide in place. Taking the previously published magnetotelluric imaging into account, we reveal the coupling relationship between the deep structures and the regional geomorphic features, and further suggest that the Lenglong Ling Fault, or the Qilian‐Haiyuan Fault, makes a difference in regional strain transferring and relief generation.