Tectonic activity in the Mediterranean area (involving migrations of old orogenic belts, formation of basins and building of orogenic systems) has been determined by the convergence of the confining plates (Nubia, Arabia and Eurasia). Such convergence has been mainly accommodated by the consumption of oceanic and thinned continental domains, triggered by the lateral escapes of orogenic wedges. Here, we argue that the implications of the above basic concepts can allow plausible explanations for the very complex time-space distribution of tectonic processes in the study area, with particular regard to the development of Trench-Arc-Back Arc systems. In the late Oligocene and lower–middle Miocene, the consumption of the eastern Alpine Tethys oceanic domain was caused by the eastward to SE ward migration/bending of the Alpine–Iberian belt, driven by the Nubia–Eurasia convergence. The crustal stretching that developed in the wake of that migrating Arc led to formation of the Balearic basin, whereas accretionary activity along the trench zone formed the Apennine belt. Since the collision of the Anatolian–Aegean–Pelagonian system (extruding westward in response to the indentation of the Arabian promontory) with the Nubia-Adriatic continental domain, around the late Miocene–early Pliocene, the tectonic setting in the central Mediterranean area underwent a major reorganization, aimed at activating a less rested shortening pattern, which led to the consumption of the remnant oceanic and thinned continental domains in the central Mediterranean area.