Tedavi görmemiş sirozu olmayan hepatit B virüs enfeksiyonu olan erkek hastalarda fibrozis şiddetini öngörmede laboratuar indekslerinin değerlendirilmesi

Abstract

We aimed to assess serum levels of AST and ALT, platelet counts, INR or serum HBV DNA levels, especially in score systems such as APRI (AST/platelet ratio), FIB-4 index and King's score, for predicting severity of fibrosis. Material and Methods: One hundred fifty treatment naive male HBV patients underwent percutaneous liver biopsy were evaluated retrospectively. For evaluating the difference in variables and scores, patients were divided into 2 groups such as no or minimal fibrosis group (fibrosis score<2) and significiant fibrosis group (fibrosis score≥2). Results: There were 79 patients (52.7%) with minimal fibrosis and 71 patients (42.3%) with significiant fibrosis. We considered that optimal cutoff values defining significant fibrosis for serum HBV DNA level was 4.