Tek doz tadalafil 20 mg verildikten üç saat sonra idrar akım hızını arttırmaktadır

Abstract

Alt üriner sistem semptomları (AÜSS) yaşlanan erkeklerde yaygın olarak görülür ve ayrıca yaşam kalitesini (YK) etkiler. AÜSS ciddiyetinin ve YK'nin değerlendirilmesi için üroflovmetri, ultrasonografi ve anketler dahil birçok araç klinisyenler tarafından yaygın olarak kullanılmaktadır. [1] ABSTRACT OBJECTIVE: Despite clinical and quality of life improvements in patients, the effect of PDE5 inhibitors on urine flow rate and post-void urine volume is still controversial. In this study, we evaluated the acute effects of tadalafil, a PDE5 inhibitor, on uroflowmetric parameters and postvoid residual urine volume (PVR). MATERIAL and METHODS: 127 men who were suffering from erectile dysfunction filled out questionnaires providing demographic information and underwent uroflowmetry and ultrasonography for residual urine volume. The patients then received 20 mg of tadalafil. Three hours later, the uroflowmetry and ultrasonography were repeated. The pre-tadalafil and post-tadalafil uroflowmetric parameters and PVR were evaluated and compared. Differences were considered statistically significant when the p value was less than 0.05. RESULTS: The mean age of the 127 men was 49.7±12.3. The mean pre-tadalafil maximal flow rate value was 16.8±5.0, and the mean post-tadalafil maximal flow rate values was 18.1±5.1 (p<0.001). The pre-and post-tadalafil average flow rate values were 9.4±3.5 and 9.9±3.6 (p=0.007), respectively. The mean PVR pre-and post-tadalafil were 30.2±21.2 and 29.4±20.8, respectively. There were statistically significant differences between pre-and post-tadalafil maximal flow rates and average flow rates. CONCLUSION: According to the results, tadalafil has acute effects on uroflowmetric parameters, but it has no effects on PVR.