Teknik Isolasi dan Penentuan Struktur Mangiferin: Senyawa Aktif dari Tanaman Mangga (Mangifera indica L.)

Mahdiyah, Luluk Luqyana Zahrah Taqiudina; Muhtadi, ‪Ahmad; Hasanah, Aliya Nur

doi:10.24198/mfarmasetika.v5i4.27238

Cited by 7 publications

(11 citation statements)

References 10 publications

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“…16 In addition, mango plants are a source of mangiferin. 9 Mangiferin belongs to the flavonoid group and belongs to xantone. Where this mangiferin has activity as an antidiabetic by inhibiting the α-glucosidase enzyme.…”

Section: Discussionmentioning

confidence: 99%

“…8 Mango leaves contain phenolic compounds (gallic acid and its derivatives, ellagic acid, strong protocatechin); Xanthones (Mangiferin and its derivatives); Flavonoids (Quercetin and its derivatives, Rhamnetin and its derivatives); Benzophenone (Maclurin and its derivatives, Iriflofenon Glycoside and its derivatives); Triterpenoids (Lupeol). 9 Mangiferin has consistent antidiabetic activity, with a peak 7 hours after oral administration. Mangiferin exhibits its antidiabetic activity by increasing insulin sensitivity.…”

Section: Introductionmentioning

confidence: 97%

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Antidiabetic of Mango (Mangifera longipes Griff.) Leves: Methanol Extract, Water Fraction, and Ethyl Acetate

Rahayuningsih

Piranti²,

Zustika³

2022

IJPST

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Mango leaves (Mangifera longipes Griff.) are used for diabetic, malaria, gastrointestinal, kidney, as well as topical treatment of wounds. The aim of this study was to determine the antidiabetic activity of methanol extract, water fraction and ethyl acetate fraction from mango leaves (Mangifera longipes Griff.). Oral Glucose Tolerance Test (OGTT) on 24 rats divided into 6 groups, namely normal; negative; positive (given acarbose 1.8 mg/200 g BW rats); methanol extract (EM), water fraction (FA), ethyl acetate fraction (FEA) with a dose of 58.8 mg/200 g BW rats. Induction of 1.35 g/200 g BW of rats glucose was carried out 30 minutes before the dosage administration. Data analysis with Paired T Test (95% confidence level). Results: In crude extract standardization, the water content was 2%, the ash content was 12.6% and the water soluble extract content was 19.5%. In crude extract and EM, flavonoids, saponins, and phenols were identified; in FA identified saponins and phenols; FEA identified flavonoids and phenols. A significant decrease in blood glucose levels at T0 and T120 in all groups (significant 2-tailed <0.05). The percentage of decline in the positive and FEA groups compared to the negative was 85.5% and 16.9%, respectively. Discussion:. Flavonoids are thought to increase antioxidant activity and inhibit α-glucosidase enzymes. Conclusion: EM, FA and FEA have antidiabetic activity with the best percentage reduction in glucose levels was FEA (16.9%).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Antidiabetic of Mango (Mangifera longipes Griff.) Leves: Methanol Extract, Water Fraction, and Ethyl Acetate

Rahayuningsih

Piranti²,

Zustika³

2022

IJPST

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“…Aktivitas antioksidan ekstrak daun jambu air (Syzygium aqueum (Burm.f) Alston) yang diekstraksi dengan pelarut 96% dilaporkan memiliki aktivitas antioksidan sebesar 10,01 ppm (3). Daun tanaman mangga (Mangifera indica L.) telah diidentifikasi mengandung mangiferin sebagai salah satu golongan polifenol yang memberikan aktivitas antioksidan (4). Aktivitas antioksidan ekstrak daun mangga (Mangifera indica L.) yang diekstraksi dengan etanol 96% dilaporkan memiliki aktivitas antioksidan sebesar 11,17 ppm (5).…”

Section: Pendahuluanunclassified

Formulasi Spray Gel Antioksidan Kombinasi Ekstrak Daun Jambu Air dan Ekstrak Daun Mangga

2022

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Daun jambu air (Syzygium aqueum (Burm.f) Alston) dan daun mangga (Mangifera indica L.) mengandung senyawa polifenol dan flavonoid yang memiliki aktivitas antioksidan yang menjadi alternative untuk mencegah penuaan dini kulit. Tujuan penelitian ini untuk mengetahui aktivitas antioksidan optimum melalui kombinasi kedua ekstrak serta menghasilkan sediaan spray gel dengan aktivitas antioksidan optimum dan stabil. Penelitian ini dilakukan meliputi tahap pembuatan ekstrak dengan metode maserasi menggunakan pelarut etanol 70%, uji aktivitas antioksidan ekstrak daun jambu air, ekstrak daun mangga tunggal serta kombinasinya perbandingan 1:1; 2:1; 1:2 dengan metode DPPH, dikembangkan dalam formula spray gel berdasarkan hasil IC50 kombinasi ekstrak dengan aktivitas antioksidan optimum atau terbaik sebesar 100xIC50; 150xIC50; 200xIC50 dan dievaluasi. Hasil penelitian menunjukan semua perbandingan kombinasi ekstrak daun jambu air (Syzygium aqueum (Burm.f) Alston) dan ekstrak daun mangga (Mangifera indica L.) memiliki aktivitas antioksidan lebih besar dibandingkan ekstrak tunggalnya antara 5,35-6,45µg/mL dengan aktivitas optimum diberikan oleh perbandingan 1:2 dengan nilai IC50 5,35 µg/mL. Aktivitas antioksidan optimum spray gel dihasilkan oleh formula dengan 200xIC50 yang mengandung 0,10% kombinasi ekstrak daun jambu air (Syzygium aqueum (Burm.f) Alston) dan ekstrak daun mangga (Mangifera indica L.) 1:2 dengan nilai IC50 27,92 µg/mL. Formula dengan 200xIC50 yang memiliki aktivitas antioksidan optimum dengan konsentrasi 0,107% kombinasi ekstrak daun jambu air (Syzygium aqueum (Burm.f) Alston) dan ekstrak daun mangga (Mangifera indica L.) 1:2 stabil dalam penyimpanan suhu 4°±2°C dan 25°±2°C.

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“…Hal ini menandakan bahwa senyawa mangiferin terdapat dalam jumlah yang besar pada sampel kulit buah mangga indramayu. Mangiferin merupakan bagian dari senyawa fenolik golongan xanthone yang memiliki aktivitas sebagai antivirus (Mahdiyah et al 2020). Mangiferin terbukti secara in silico mampu berperan dalam penghambatan kerja protein penyebab infeksi virus dengue (DENV) (Herman 2019).…”

Section: Analisis Lc-msunclassified

“…SARS-CoV-2 mengikat reseptor ACE2 dengan afinitas 10 kali lebih tinggi dibandingkan SARS-CoV (Atmojo et al 2020). ACE2 adalah protein membran pada sel alveolus yang berperan sebagai pintu masuk virus ke dalam tubuh manusia (Hasanah et al 2020). Salah satu upaya pencegahan Covid-19 ialah dengan menghambat enzim ACE2 yang akan berikatan dengan virus menggunakan senyawa bioaktif pada kulit mangga.…”

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Potency of Bioactive Compounds in Indramayu Mango Peel Waste to Inhibit ACE2

et al. 2021

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According to reports, mango peel contains bioactive compounds—especially phenolic—threefold higher than the flesh. This issue underlies the research that aims to identify bioactive compounds from Indramayu mango peel which have the potential as ACE2 inhibitors. The study was initiated by extracting mango peel simplicia using aquadest, then carried out with phytochemical screening, and identification of compound content by LC-MS. The extraction obtained 21.3% of yield. The results of phytochemical screening showed that secondary metabolites in the form of alkaloids, flavonoids, saponins, and tannins were identified in the mango peel. At the same time, the LC-MS fragmentation results obtained 40 compounds based on the largest sample area. The result from fragmentation were tested for Lipinski bioavailability prediction and ADMET test and obtained 10 potential compounds. Molecular docking was performed on the ACE2 receptor with 10 sample ligands and 1 comparison ligand using YASARA Structure. All of the sample ligands (from Lipinski and ADMET test) showed higher free energies than comparison ligand, chloroquine. Mangiferin is a typical mango compound identified in LC-MS, had inhibitor activity against ACE2. Two-dimensional visualization using Discovery Studio showed mangiferin interaction with the receptor via hydrogen bond, hydrogen carbon bond and phi-anion interactions at three amino acid residues (Thr371, Glu375, Glu402) on the active site of ACE2. Keywords: ACE2, bioactive compound, mango peel, mangiferin, waste

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Teknik Isolasi dan Penentuan Struktur Mangiferin: Senyawa Aktif dari Tanaman Mangga (Mangifera indica L.)

Cited by 7 publications

References 10 publications

Antidiabetic of Mango (Mangifera longipes Griff.) Leves: Methanol Extract, Water Fraction, and Ethyl Acetate

Antidiabetic of Mango (Mangifera longipes Griff.) Leves: Methanol Extract, Water Fraction, and Ethyl Acetate

Formulasi Spray Gel Antioksidan Kombinasi Ekstrak Daun Jambu Air dan Ekstrak Daun Mangga

Potency of Bioactive Compounds in Indramayu Mango Peel Waste to Inhibit ACE2

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