Telangiectatic Osteosarcoma

Colomina, Jordi; Peiró, Ana M.; Trullols, L.; Gracia, I.

doi:10.1177/230949901302100124

Cited by 8 publications

(9 citation statements)

References 17 publications

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“…TOS is a rare subtype of osteosarcoma that is present in 2–12% of all osteosarcoma cases (18). TOS is characterized by the presence of numerous blood-filled cavities divided by septa (19,20). Gao et al (21) described various features of TOS, including high serum ALP levels, cortical destruction, the presence of a soft tissue mass and thick septal enhancement, as observed using MRI.…”

Section: Discussionmentioning

confidence: 99%

Diagnosing and discriminating between primary and secondary aneurysmal bone cysts

et al. 2017

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Aneurysmal bone cysts (ABCs) are benign bony lesions frequently accompanied by multiple cystic lesions and aggressive bone destruction. They are relatively rare lesions, representing only 1% of bone tumors. The pathogenesis of ABCs has yet to be elucidated. In the present study, a series of 22 cases of primary and secondary ABC from patients treated in Department of Orthopedic Surgery, Kagoshima University Hospital (Kagoshima, Japan) from 2001–2015 were retrospectively analyzed. The average age at the time of diagnosis of primary ABC was 17.9 years. Intralesional curettage and artificial bone grafting were performed in the majority of the patients with primary ABC. The local recurrence rate following curettage for primary ABC was 18%, and the cause of local recurrence was considered to be insufficient curettage. Although no adjuvant therapy was administered during the surgeries, it may assist the prevention of local recurrence in certain cases. The cases of secondary ABC were preceded by benign bone tumors, including fibrous dysplasia, giant cell tumors, chondroblastoma and non-ossifying fibroma. The features of the secondary ABC typically reflected those of the preceding bone tumor. In the majority of cases, distinguishing the primary ABC from the secondary ABC was possible based on characteristic features, including age of the patient at diagnosis and the tumor location. In cases that exhibit ambiguous features, including a soft tissue mass or a thick septal enhancement on the preoperative magnetic resonance images, a biopsy must be obtained in order to exclude other types of aggressive bone tumors, including giant cell tumor, osteosarcoma and telangiectatic osteosarcoma.

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Section: Discussionmentioning

confidence: 99%

Diagnosing and discriminating between primary and secondary aneurysmal bone cysts

et al. 2017

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“…By increasing unexpected chance of micro-metastasis, fracture is theoretically an adverse event. However, it has not been found to be an indicator of either recurrence or overall survival 44041…”

Section: Traditional Prognostic Factorsmentioning

confidence: 99%

“…The risk of mortality is significantly more in those with metastases at initial presentation 303138415253. They are also likely to have shorter EFS than their counterparts with limited disease 2841. Some authors do not consider stage at presentation as a prognostic factor, rather a consequence of other poor prognostic factors 7…”

Section: Traditional Prognostic Factorsmentioning

confidence: 99%

“…Huvos criteria (>90% necrosis-good response) is most commonly followed 54555657. Poor response is a strong predictor of local recurrence, metastases and overall survival 28303137415055. The preferential sites where viable malignant cells are most likely to persist include soft tissues, cortex, sub-cortex, ligaments and areas in contact with cartilage 57.…”

Section: Traditional Prognostic Factorsmentioning

confidence: 99%

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Osteosarcoma: Diagnostic dilemmas in histopathology and prognostic factors

Wadhwa

2014

IJOO

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Osteosarcoma (OS), the commonest malignancy of osteoarticular origin, is a very aggressive neoplasm. Divergent histologic differentiation is common in OS; hence triple diagnostic approach is essential in all cases. 20% cases are atypical owing to lack of concurrence among clinicoradiologic and pathologic features necessitating resampling. Recognition of specific anatomic and histologic variants is essential in view of better outcome. Traditional prognostic factors of OS do stratify patients for short term outcome, but often fail to predict their long term outcome. Considering the negligible improvement in the patient outcome during the last 20 years, search for novel prognostic factors is in progress like ezrin vascular endothelial growth factor, chemokine receptors, dysregulation of various micro ribonucleic acid are potentially promising. Their utility needs to be validated by long term followup studies before they are incorporated in routine clinical practice.

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“…Osteosarcoma is one of the common primary malignant bone tumor diagnosed in children and teenagers (1,2). Current chemotherapy regimens of osteosarcoma are based on a combination of doxorubicin, methotrexate (MTX) and cisplatin (3)(4)(5)(6). Only 50-60% of tumors are chemosensitive, demonstrating the dismal outcome that occurs far too often in osteosarcoma (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway

Peng

Lee

Hour

et al. 2013

International Journal of Oncology

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Curcumin has potential anticancer activity and has been shown to be involved in several signaling pathways including differentiation and apoptosis. Our previous study showed that water-soluble PLGA curcumin nanoparticles (Cur-NPs) triggered apoptotic cell death through regulation of the function of MDR1 and the production of reactive oxygen species (ROS) in cisplatin-resistant human oral cancer CAR cells. In this study, we investigated the anti-proliferative effects of Cur-NPs on human osteosarcoma U2OS cells. The morphology of Cur-NPs showed spherical shape by TEM analysis. The encapsulation efficiency of curcumin in Cur-NPs prepared by single emulsion was 90.5 ± 3.0%. Our results demonstrated that the curcumin fragments on the mass spectrum of Cur-NPs and the peaks of curcumin standard could be found on the Cur-NPs spectrum by 1H-NMR spectra analysis. Cur-NPs induced anti-proliferative effects and apoptosis in U2OS cells. Compared to the untreated U2OS cells, more detectable amount of Cur-NPs was found inside the treated U2OS cells. Cur-NPs induced DNA fragmentation and apoptotic bodies in U2OS cells. Both the activity and the expression levels of caspases-3/-7 and caspase-9 were elevated in the treated U2OS cells. Cur-NPs upregulated the protein expression levels of cleaved caspase-3/caspase-9, cytochrome c, Apaf-1 and Bad and downregulated the protein expression level of p-Akt in U2OS cells. These results suggest Cur-NPs are effective in enhancing apoptosis in human osteosarcoma cells and thus could provide potential for cancer therapeutics.

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Telangiectatic Osteosarcoma

Cited by 8 publications

References 17 publications

Diagnosing and discriminating between primary and secondary aneurysmal bone cysts

Diagnosing and discriminating between primary and secondary aneurysmal bone cysts

Osteosarcoma: Diagnostic dilemmas in histopathology and prognostic factors

Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway

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