Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan

Efficacy and Safety of Telaprevir, Pegylated Interferon α-2b and Ribavirin Triple Therapy in Japanese Patients Infected with Hepatitis C Virus Genotype 1b

“…Antiallergic agents and steroid treatment reduced the occurrence of skin disorders, one of the notable side effects of TVR in phase III trials (8,9). However, one patient with advanced hepatic fibrosis, diabetes and hypertension developed bacterial pericarditis after receiving a high dose of oral glucocorticoid, suggesting that a warning for steroid use is necessary in high-risk patients.…”

“…A phase III trial in treatment-naïve patients with HCV genotype 1 found that SVR rates were higher with triple therapy, consisting of TVR plus PEG-IFN/RBV, than with dual therapy (73.0% vs. 49.2%) (8). In treatment-experienced patients, however, SVR rates differed greatly between relapsers and non-responders (88.1% vs. 34.4%) (9).…”

Peg-interferon plus ribavirin with or without boceprevir or telaprevir for HCV genotype 1: A meta-analysis on role of response predictors

“…Of these, 302 citations were considered potentially relevant but only 7 [28][29][30][31][32][33][34] met the inclusion criteria ( Figure 1). Three post-hoc analyses [35][36][37] were also included for a more extensive knowledge of the original studies: the Poordad study [35] for the IL28-B data of the Poordad [29] and Bacon studies [30]; the Bruno study [36] for the IL28-B data of the Poordad [29] and Bacon studies [30]; the Pol study [37] for the fibrosis data of the Zeuzem study [32].…”

“…Four trials [28,29,31,33] enrolled therapy-naïve patients and three [30,32,34] relapser patients to previous Peg-IFN+ribavirin treatment. Three studies experimented telaprevir [31][32][33] and four boceprevir [28][29][30]34] as the DAAs. In all studies, the ribavirin dose was weight-based ranging from 600 to 1,400 mg. All patients treated with dual therapy received treatment for 48 weeks.…”

“…The correlation between the achievement of SVR and the entity of HCV load was investigated using different cut-off values of high HCV RNA: 800,000 IU/mL [29][30][31][32]36], 600,000 IU/mL [28], and 7 log 10 IU/mL [33].…”