Background: CPAP adherence patterns are often established very early in the course of therapy. Our objective was to quantify patients' perception of CPAP therapy using a 6-item questionnaire administered in the morning following CPAP titration. We hypothesized that questionnaire responses would independently predict CPAP adherence during the fi rst 30 days of therapy. Methods: We retrospectively reviewed the CPAP perception questionnaires of 403 CPAP-naïve adults who underwent inlaboratory titration and who had daily CPAP adherence data available for the fi rst 30 days of therapy. Responses to the CPAP perception questionnaire were analyzed for their association with mean CPAP adherence and with changes in daily CPAP adherence over 30 days. Results: Patients were aged 52 ± 14 years, 53% were women, 54% were African American, the mean body mass index (BMI) was 36.3 ± 9.1 kg/m 2 , and most patients had moderate-severe OSA. Four of 6 items from the CPAP perception questionnaireregarding diffi culty tolerating CPAP, discomfort with CPAP pressure, likelihood of wearing CPAP, and perceived health benefi t-were signifi cantly correlated with mean 30-day CPAP adherence, and a composite score from these 4 questions was found to be internally consistent. Stepwise linear regression modeling demonstrated that 3 variables were signifi cant and independent predictors of reduced mean CPAP adherence: worse score on the 4-item questionnaire, African American race, and non-sleep specialist ordering polysomnogram and CPAP therapy. Furthermore, a worse score on the 4-item CPAP perception questionnaire was consistently associated with decreased mean daily CPAP adherence over the fi rst 30 days of therapy.
Conclusions:In this pilot study, responses to a 4-item CPAP perception questionnaire administered to patients immediately following CPAP titration independently predicted mean CPAP adherence during the fi rst 30 days. Further prospective validation of this questionnaire in different patient populations is warranted.
S C I E N T I F I C I N V E S T I G A T I O N ST he prevalence of obstructive sleep apnea (OSA) has been well documented 1 and is expected to increase as the prevalence of obesity increases.2 Untreated OSA is associated with not just increased cardiovascular 3 and metabolic risks, 4 but also with myriad comorbidities including decreased quality of life, 5 depressed mood, 6 decreased cognitive function, 7 increased risk of motor vehicle and occupational accidents, 8,9 and increased risk of pregnancy complications.10 Though continuous positive airway pressure (CPAP) therapy is highly effi cacious 11 and is associated with decreased cardiovascular morbidity and mortality 12,13 and metabolic morbidity, 14,15 treatment effectiveness depends largely on patient adherence, which is often suboptimal. 16 Moreover, long-term patient adherence is typically established within the fi rst week of CPAP therapy.
17-19Certain factors have already been associated with poor adherence to CPAP therapy: lack of sleep specialist consultation ...