Telemonitored Human Circadian Temperature Dynamics During Daily Routine

Abstract

BackgroundCircadian rhythms in body temperature coordinate peripheral molecular clocks, hence they could potentially predict optimal treatment timing (chronotherapy) in individual patients. Circadian parameters in chest surface body temperature (Chesttemp) were recorded remotely and in real time through the use of wearable sensors.MethodsThe dynamics of circadian oscillations in Chesttemp and core body temperature (Coretemp) and their moderation by sex and age were analysed in 38 men and 50 women, aged 21–78 years. In two studies (ST1 and ST2), Chesttemp was measured every minute and teletransmitted using a BLE-connected sensor for 3.6–28.3 days. Additionally, in ST2, Coretemp was recorded per minute in 33 age- and sex-stratified subjects using electronic ingestible pills with radio-frequency transmissions. Circadian parameters were computed using spectral analysis and cosinor modelling. The temporal relations between Chesttemp and Coretemp cosinor parameters were summarised with principal component (PC) analysis. The effect of sex and age was analysed through multivariate regression.ResultsUsing spectral analysis, a dominant period of 24- or 12-h was identified in 93.2% of the Chesttemp and in 100% of the Coretemp time series. The circadian parameters varied largely between-subjects both for Chesttemp (ranges: mesors, 33.2–36.6°C; amplitudes, 0.2–2.5°C; acrophases, 14:05–7:40), and Coretemp (mesors, 36.6–37.5°C; amplitudes, 0.2–0.7°C; bathyphases, 23:50–6:50). Higher PC loadings mainly corresponded to (i) large Chesttemp amplitudes, and phase advance of both temperature rhythms for the first PC (PC1, 27.2% of variance var.), (ii) high mesors in both temperature rhythms for PC2 (22.4% var.), and (iii) large Coretemp amplitudes for PC3 (12.9% var.). Chesttemp and Coretemp mesors and PC2 loadings decreased in females, while remaining quite stable in males as a function of age. In contrast, Coretemp amplitude and PC3 loadings increased with age in females, but decreased in males. Finally, older subjects, both female and male, displayed a reduction in ultradian variabilities, and an increase in both Chesttemp circadian amplitude and PC1 loadings.InterpretationThe dynamics relations between Chesttemp and Coretemp rhythms were largely moderated by age and sex, with results suggesting that treatment timing could be most critical for therapeutic index in women and in order people.

Efficient assessment of real-world dynamics of circadian rhythms in heart rate and body temperature from wearable data

“…The estimates of amplitude defined to be half the range of the oscillatory signal increased when increasing the number of harmonics (figure 4 g and table 1). It is noteworthy that our amplitude estimate obtained with the reasonable two-harmonic model (0.896∘C) was consistent with the previously reported one (0.88∘C) obtained by fitting the two harmonics to the BT data collected using a wearable chest patch (Movisens, Karlsruhe, Germany) [27]. Moreover, the amplitude estimates of 24 h rhythm (i.e.…”

Digital circadian and sleep health in individual hospital shift workers: A cross sectional telemonitoring study

“…Longitudinal telemonitored data of high quality were gathered from 140 health professionals working as DS (77 individuals) or NS (63 individuals). The distribution of the circadian parameters in rest-activity and chest surface temperature of the DS in Circadiem was consistent with earlier results from telemonitoring “day-active” people using the same system, 30 , 48 , 49 which further highlights the significance of the alterations found in the NS. Indeed, NS experienced significantly worse estimated rest quality (p1-1) and circadian activity rhythm (RI) and a delayed centre time of rest, although they achieved similar rest duration by taking more frequent and longer naps.…”

Digital Circadian and Sleep Health in Individual Hospital Shift Workers: A Cross Sectional Telemonitoring Study

“…Longitudinal telemonitored data of high quality were gathered from 140 health professionals working as DS (77 individuals) or NS (63 individuals). The distribution of the circadian parameters in rest-activity and chest surface temperature of the DS in Circadiem was consistent with earlier results from telemonitoring "dayactive" people using the same system, 30,48,49 which further highlights the significance of the alterations found in the NS. Indeed, NS experienced significantly worse estimated rest quality (p1-1) and circadian activity rhythm (RI) and a delayed centre time of rest, although they achieved similar rest duration by taking more frequent and longer naps.…”