Telencephalic morphogenesis during the process of neurulation: An experimental study using quail–chick chimeras

Pombero, Ana; Martı́nez, Salvador

doi:10.1002/cne.21933

Cited by 24 publications

(28 citation statements)

References 43 publications

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“…Fate-mapping studies in the chick showed that the distalmost part of the ov at stages 9 and 10 contributes to the eye, whereas the dorsalmost region of the ov consists of telencephalic precursors (Garcia-Lopez et al, 2009;Pombero and Martinez, 2009). Consistent with this, RPE specification initiates distally underneath the surface ectoderm, but soon the MITF domain becomes restricted to the dorsal ov and optic cup ( Fig.…”

Section: Bmp and Wnt Ligands Expressed In The Surface Ectoderm Specifmentioning

confidence: 99%

RPE specification in the chick is mediated by surface ectoderm-derived BMP and Wnt signalling

Steinfeld

Coronato

et al. 2013

Development

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The retinal pigment epithelium (RPE) is indispensable for vertebrate eye development and vision. In the classical model of optic vesicle patterning, the surface ectoderm produces fibroblast growth factors (FGFs) that specify the neural retina (NR) distally, whereas TGFβ family members released from the proximal mesenchyme are involved in RPE specification. However, we previously proposed that bone morphogenetic proteins (BMPs) released from the surface ectoderm are essential for RPE specification in chick. We now show that the BMP-and Wnt-expressing surface ectoderm is required for RPE specification. We reveal that Wnt signalling from the overlying surface ectoderm is involved in restricting BMP-mediated RPE specification to the dorsal optic vesicle. Wnt2b is expressed in the dorsal surface ectoderm and subsequently in dorsal optic vesicle cells. Activation of Wnt signalling by implanting Wnt3a-soaked beads or inhibiting GSK3β at optic vesicle stages inhibits NR development and converts the entire optic vesicle into RPE. Surface ectoderm removal at early optic vesicle stages or inhibition of Wnt, but not Wnt/β-catenin, signalling prevents pigmentation and downregulates the RPE regulatory gene Mitf. Activation of BMP or Wnt signalling can replace the surface ectoderm to rescue MITF expression and optic cup formation. We provide evidence that BMPs and Wnts cooperate via a GSK3β-dependent but β-catenin-independent pathway at the level of pSmad to ensure RPE specification in dorsal optic vesicle cells. We propose a new dorsoventral model of optic vesicle patterning, whereby initially surface ectoderm-derived Wnt signalling directs dorsal optic vesicle cells to develop into RPE through a stabilising effect of BMP signalling.

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Section: Bmp and Wnt Ligands Expressed In The Surface Ectoderm Specifmentioning

confidence: 99%

RPE specification in the chick is mediated by surface ectoderm-derived BMP and Wnt signalling

Steinfeld

Coronato

et al. 2013

Development

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“…While the early expression of Sulf1 in the telencephalon was restricted to the roof plate, presumptive region of the choroid plexus and the septum (Pombero and Martinez, 2009), new areas appeared in the subpallium at HH26 (E5): the POA and Pa. Then, between E8 (HH34) and E18 (HH44), we observed new pallial domains expressing Sulf1 in the telencephalon.…”

Section: Sulf1 Gene Expression At Later Stages In the Telencephalonmentioning

confidence: 72%

Expression analysis of Sulf1 in the chick forebrain at early and late stages of development

García-López¹,

Soula

2009

Developmental Dynamics

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Sulfatase 1 is a secreted enzyme that modulates the sulfation state of heparan sulfate proteoglycans (HSPGs), which are potential key regulators of diverse developmental signals during embryonic patterning. In the present work, we have analyzed the Sulf1 gene expression pattern during chicken forebrain development. Our results indicate that, at early developmental stages, chicken Sulf1 is expressed in the alar and basal plate of the secondary prosencephalon (telencephalon and hypothalamus, respectively) as well as in the diencephalic basal and floor plates. Later in development, Sulf1 is expressed by a subset of nuclei derived from these regions. prosomere 1 (pretectum) p1MT p1 medial terminal nucleus p1PAG p1 periaqueductal gray p1PEW p1 pre-Edinger-Westphal nucleus p1Rt p1 reticular formation p1SNC p1 substantia nigra, compact part p1Tg p1 tegmentum area p1VTA p1 ventral tegmental area p2 prosomere 2 (thalamus) p2PAG p2 periaqueductal gray p2Tg p2 tegmentum area p2VTA p2 ventral tegmental area p3 prosomere 3 (prethalamus) p3Tg p3 tegmentum area p3VTA p3 ventral tegmental area pc posterior commissure Pe periventricular stratum PH posterior hypothalamic nucleus Pi pineal gland POA preoptic area PRot perirotundic area PrPT principal pretectal nucleus of the commissural pretectum PThB basal prethalamic nucleus Rh rhombencephalon rh1 rombomere 1 RM retromammillary nucleus RMC red nucleus, magnocellular part Rot rotundus nucleus RPC red nucleus, parvicellular part SAC stratum album centrale of the tectum SCh suprachiasmatic nucleus Se septum SGC stratum griseum centrale of the tectum SGFS stratum griseum et fibrosum superficiale of the tectum SHb subhabenular nucleus SLPG semilunar perigeniculate nucleus sm stria medullaris SMi superficial microcellular nucleus SP secondary prosencephalon SPa subparaventricular nucleus SPC superficial parvicellular nucleus of the thalamus SpL lateral spiriform nucleus SPT subpretectal nucleus SRot subrotundus nucleus of the thalamus STh subthalamic nucleus TC tuber cinereum area TEL telencephalom TGC tectal gray, central stratum vCaPa caudal paraventricular area, ventral part VisCo visual nidopallial nucleus, core region VisSh visual nidopallial nucleus, shell region VTgM ventral tegmental area of mammillary region VTgp1 ventral tegmental area of prosomere 1 VTgRM ventral tegmental area of retromammillary region xso supraoptic decussation ZLI intrathalamic limitans zone

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“…Cell prolif eration is locally regulated to shape the complex structure of the brain. For instance, the cells in the alar region of the neural plate proliferate more than those in the floor region to enable neural tube closure (13). The cells in the prosencephalic vesicle proliferate more than the cells at the boundary between the prosencephalon and the mesencephalon to enable prosencephalon expansion (12).…”

Section: Mll2 Nc/ncmentioning

confidence: 99%

“…When neural progenitor cells increase in population, the brain vesicles experience robust size expansion, with a cell cycle time of 7 hours in the prosencephalon and 8.5 hours in more caudal regions (10,11). Importantly, cell proliferation is tightly controlled during brain expansion (12,13). Poor cell cycle regulation is associated with a variety of head malformations (1,2).…”

Section: Introductionmentioning

confidence: 99%

Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription

Takeda¹,

Sasagawa²,

Oyama³

et al. 2015

J. Clin. Invest.

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Telencephalic morphogenesis during the process of neurulation: An experimental study using quail–chick chimeras

Abstract: ABSTRACT

Cited by 24 publications

References 43 publications

RPE specification in the chick is mediated by surface ectoderm-derived BMP and Wnt signalling

RPE specification in the chick is mediated by surface ectoderm-derived BMP and Wnt signalling

Expression analysis of Sulf1 in the chick forebrain at early and late stages of development

Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription

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