Background: Self-criticism is one of the personal characteristics that led to the inability to communicate properly with others, and as a result of this feeling, people blame themselves constantly. Objectives: This study was aimed to comprise the self-criticism in patients with obsessive-compulsive as well as major depression disorders and normal individuals. Methods: Study methodology was a casual-comparative of post ex facto type. The study population included all patients with major depression and obsessive-compulsive referred to psychiatric hospitals, psychiatric clinics, private and public centers of counseling, psychological services, and normal people. The present study consisted of 20 people with major depression, 20 people with obsessive-compulsive, and 40 normal people who were selected by purposive sampling method. To analyze the data, ANOVA was used. Results: Its results showed that the difference between the study groups in self-criticism was statistically significant. Scheffe post hoc test results showed that there is a significant difference between depressed and healthy groups, obsessive-compulsive and healthy groups, as well as depressed and obsessive-compulsive groups. Furthermore, the average self-compulsive in the depressed group is higher compared to other groups. Conclusions: Self-criticism is one of the traits vulnerable to depression; this trait not only causes depression, but is also affected by the symptoms of depression.