The future of space exploration is defined by a close partnership between intelligent autonomous robots and humans. These robots serve as extensions in space which do tasks in dangerous or harsh environments where direct human participation is impossible. In recent years, researchers, commercial firms and space organizations have made considerable advances in the creation of autonomous and remotely controlled space robots. These robots serve an important role in space exploration, assisting people on the International Space Station (ISS) and exploring distant celestial bodies. These robots require highly developed tele-operation interfaces and HMI designs to bridge the knowledge gap between human competency and machine execution. This chapter provides a thorough analysis of the dynamic interactions between intelligent autonomous robots and humans. It also offers insights for space agencies, academics, engineers and everyone else interested in the fascinating field of space technology and exploration which lays out a vision for the future of autonomous systems and space robots.