Purpose: For cardiovascular patients, family caregivers play a vital role in daily nursing and cardiac emergencies. This study aimed to evaluate the effect of patient-centered CPR education (PCE) for family caregivers of patients with cardiovascular diseases. Methods: Fifty-four participants were randomly assigned to the PCE or control group. The PCE group received tailored counseling on overall cardiovascular disease information and CPR followed by interactive instructor-guided CPR training and re-education follow-up by telephone 2 weeks later. The control group received only video-based CPR self-education and booklets. Cardiovascular disease and CPR knowledge and self-efficacy were measured before (pre-test), immediately after (post-test 1), and 4 weeks after the PCE (post-test 2). CPR skills and performance were measured pre-test and at post-test1. Results: The PCE group demonstrated significant improvements in knowledge (F=91.09, p <.001), self-efficacy (F=15.19, p <.001) and CPR skills and performance (F=8.10, p =.008), as well as significant differences over time (knowledge: F=364.25, p <.001; self-efficacy: F=1162.28, p <.001; CPR skills and performance: F=1798.81, p <.001). There were significant group-by-time interactions for knowledge (F=8.10, p =.001), self-efficacy (F=4.30, p =.019) and CPR skills and performance (F=4.81, p =.036) by repeated measures ANO-VA. Conclusion: This is the first study to demonstrate the effects of a patient-centered intervention with CPR education tailored for patients' and family caregivers' preferences, needs, and lifestyles. The results of this study encourage the use of tailored, patient-centered interventions in cardiovascular nursing practice. Address reprint requests to : Suh, Eunyoung E. Therefore, we incorporated the "patient-centered intervention" concept with CPR training. The recently developed concept of patient-centered intervention emphasizes: 1) the individual patient's preferences, needs, and values; 2) the interaction between patients, family caregivers, and healthcare providers; and 3) patient-participation in treatment plan and lifestyle modification [11,12]. Recently, patient-and family-centered intervention studies have been conducted, demonstrating the effects of improving things such as patients' and family caregivers' quality of life, efficiency, knowledge, and satisfaction [13,14].Combining CPR training and patient-centered intervention, family caregivers would learn how to manage the patient's cardiovascular disease in daily life and how to respond to a cardiovascular emergency. This would increase the knowledge, motivation, and confidence of family caregivers.This study was conducted to investigate the effects of patientcentered CPR education (PCE) on knowledge, self-efficacy, and performance in a cardiac emergency of family caregivers of cardiovascular patients. The concept of patient-centered intervention was applied via counseling and interactive CPR education provided by a nurse. We hypothesized that participants in PCE would demonstrate 1) i...