Reinhart (1983) proposed that quantificational binding is subject to a surface c-command condition. Her claim has been widely accepted in the literature on the syntax-semantics interface. However, Barker (2012) presented systematic counterevidence against the c-command requirement from English. The current paper addresses the role of c-command constraints in the grammar of three phenomena in German: relative quantifier scope, quantificational binding, and negative polarity. The results of a large corpus study are presented that demonstrate empirically that scope of one quantifier over another, quantificational binding, and the licensing of negative polarity items in German are systematically possible in structural configurations where surface c-command cannot reasonably be assumed to obtain. Further corpus evidence is produced which shows that the non-c-commanding quantifiers in the examples typically occur in contexts where the set they quantify over is discourse-old or easy to accommodate. The overall picture that emerges from the empirical evidence is that topicality motivates wide scope, and scope rather than c-command licenses negative polarity items and bound pronouns.