Telfairia occidentalis seed extract protects against oxidative stress, inflammation and some haematological disorders associated with atrazine-induced prostate cancer in rats

Adedosu, Olaniyi T.; Badmus, Adedoyin; Adeleke, G. E.; Raji, Ramat Onyeneoyiza

doi:10.1016/s0959-8049(17)30393-3

Cited by 5 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here, we first found that the triazine herbicide bioavailability was increased in rats after 3 and 7 days of ampicillin administration. In previous studies, exposure to triazine herbicides such as atrazine, terbuthylazine, and ametryn would cause oxidative stress, change antioxidant systems, and lead to DNA damage [39–41]. Thus, the increased bioavailability may pose a higher potential risk to health hazards when people are exposed to herbicides at a relatively high level after taking antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota

et al. 2018

View full text Add to dashboard Cite

BackgroundAntibiotics are commonly used worldwide, and pesticide is a kind of xenobiotic to which humans are frequently exposed. The interactive impact of antibiotics on pesticides has rarely been studied. We aim to investigate the effects of antibiotics on the pesticide exposure risk and whether gut microbiota altered by antibiotics has an influence on pesticide bioavailability. Furthermore, we explored the mechanisms of gut microbiota affecting the fate of pesticides in the host.ResultsThe oral bioavailability of triazine herbicides significantly increased in the rats treated with ampicillin or antibiotic cocktails. The antibiotic-altered gut microbiota directly influenced the increased pesticide bioavailability through downregulating hepatic metabolic enzyme gene expression and upregulating intestinal absorption-related proteins.ConclusionsAntibiotics could increase the pesticide bioavailability and thereby may increase the pesticide exposure risk. The antibiotic-altered gut microbiota that could alter the hepatic metabolic enzyme gene expression and intestinal absorption-related proteome was a critical cause of the increased bioavailability. This study revealed an undiscovered potential health impact of antibiotics and reminded people to consider the co-exposed xenobiotics when taking antibiotics.Electronic supplementary materialThe online version of this article (10.1186/s40168-018-0602-5) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In a number of studies (summarised in Table 1), sub-chronic exposure to 300 mg kg -1 of atrazine resulted in higher MDA levels in the liver and adrenal cortex of rats (70,72,79). Higher MDA was also detected in the testes, epididymis, brain, liver, and kidney of rats exposed to 25-200 mg kg -1 of atrazine (69,73,76,80). As for the antioxidant defences in rats, higher atrazine doses (300 mg kg -1 ) increased the activities of CAT, SOD, GPX, and GST and decreased GSH levels in blood and liver (68,70,72), whereas all of these markers dropped in the adrenal cortex (79).…”

Section: Involvement Of Oxidative Stress In Atrazine Toxicitymentioning

confidence: 99%

“…As for the antioxidant defences in rats, higher atrazine doses (300 mg kg -1 ) increased the activities of CAT, SOD, GPX, and GST and decreased GSH levels in blood and liver (68,70,72), whereas all of these markers dropped in the adrenal cortex (79). At doses from 25 to 200 mg kg -1 , atrazine lowered CAT activity in rat testis, epididymis, brain, liver, and kidney (69,71,73,76,80).…”

Section: Involvement Of Oxidative Stress In Atrazine Toxicitymentioning

confidence: 99%

Oxidative stress in triazine pesticide toxicity: a review of the main biomarker findings

Semren

Žunec

Pizent

2018

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

This review article provides a summary of the studies relying on oxidative stress biomarkers (lipid peroxidation and antioxidant enzymes in particular) to investigate the effects of atrazine and terbuthylazine exposure in experimental animals and humans published since 2010. In general, experimental animals showed that atrazine and terbuthylazine exposure mostly affected their antioxidant defences and, to a lesser extent, lipid peroxidation, but the effects varied by the species, sex, age, herbicide concentration, and duration of exposure. Most of the studies involved aquatic organisms as useful and sensitive bio-indicators of environmental pollution and important part of the food chain. In laboratory mice and rats changes in oxidative stress markers were visible only with exposure to high doses of atrazine. Recently, our group reported that low-dose terbuthylazine could also induce oxidative stress in Wistar rats. It is evident that any experimental assessment of pesticide toxic effects should take into account a combination of several oxidative stress and antioxidant defence biomarkers in various tissues and cell compartments. The identified effects in experimental models should then be complemented and validated by epidemiological studies. This is important if we wish to understand the impact of pesticides on human health and to establish safe limits.

show abstract

Histopathological, Immunohistochemical, And Molecular Alterations In Brain Tissue And Submandibular Salivary Gland Of Atrazine-Induced Toxicity In Male Rats

Ahmed

AbuBakr

Ahmad

et al. 2022

Environ Sci Pollut Res

View full text Add to dashboard Cite

Telfairia occidentalis seed extract protects against oxidative stress, inflammation and some haematological disorders associated with atrazine-induced prostate cancer in rats

Cited by 5 publications

References 0 publications

Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota

Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota

Oxidative stress in triazine pesticide toxicity: a review of the main biomarker findings

Histopathological, Immunohistochemical, And Molecular Alterations In Brain Tissue And Submandibular Salivary Gland Of Atrazine-Induced Toxicity In Male Rats

Contact Info

Product

Resources

About