Tellurite Reduction in Schizosaccharomyces pombe

Smith, D. G.

doi:10.1099/00221287-83-2-389

Cited by 18 publications

(7 citation statements)

References 4 publications

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“…The location of copper reductase appears to be the cell wall and this process may have a role in regulation of copper uptake (Wakatsuki et al, 19916). Fungal reductions of metalloids include reduction of tellurite to elemental tellurium, wbich can appear as a black deposit, located on tbe endoplasmic reticulum (Corfield & Smith, 1970;Smith, 1974) and the reduction of selenate or selenite to form amorpbous selenium which imparts a red colour to fungal colonies owing to deposition, chiefly in walls and membranes (Konetzka, 1977).…”

Section: Metal Transformationsmentioning

confidence: 99%

Interactions of fungi with toxic metals

1993

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SUMMARY This review details the major interactions of fungi with toxic metal species. Physico‐chemical and biological aspects are discussed including definitions and classification of metals in biological contexts, mechanisms of metal fungitoxicity, resistance and tolerance, environmental influences and the occurrence of fungi in metal‐polluted habitats. Cellular interactions include extracellular precipitation and complexation, binding to cell walls, transport of monovalent and divalent metal cations, intracellular fates of toxic metal species (including metal‐binding proteins and peptides, and vacuolar compartmentation), and metal transformations including organometal(loid) synthesis. Significant interactions between metals and mycorrhizal fungi and macrofungi are summarized with reference to the amelioration of plant phytotoxicity and metal accumulation respectively. Biotechnological aspects of metal‐fungal interactions relate to the biological treatment of metal‐contaminated effluents and waste streams for metal removal/recovery and environmental protection.

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Section: Metal Transformationsmentioning

confidence: 99%

Interactions of fungi with toxic metals

1993

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“…It has long been known that different bacterial species vary in their tolerance to Te(IV), which has prompted the inclusion of TeO 3 2Ϫ in a variety of selective bacteriological tests (48). However, the mechanistic basis of this variance remains elusive.…”

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confidence: 99%

Sulfate Assimilation Mediates Tellurite Reduction and Toxicity in Saccharomyces cerevisiae

et al. 2010

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Despite a century of research and increasing environmental and human health concerns, the mechanistic basis of the toxicity of derivatives of the metalloid tellurium, Te, in particular the oxyanion tellurite, Te(IV), remains unsolved. Here, we provide an unbiased view of the mechanisms of tellurium metabolism in the yeast Saccharomyces cerevisiae by measuring deviations in Te-related traits of a complete collection of gene knockout mutants. Reduction of Te(IV) and intracellular accumulation as metallic tellurium strongly correlated with loss of cellular fitness, suggesting that Te(IV) reduction and toxicity are causally linked. The sulfate assimilation pathway upstream of Met17, in particular, the sulfite reductase and its cofactor siroheme, was shown to be central to tellurite toxicity and its reduction to elemental tellurium. Gene knockout mutants with altered Te(IV) tolerance also showed a similar deviation in tolerance to both selenite and, interestingly, selenomethionine, suggesting that the toxicity of these agents stems from a common mechanism. We also show that Te(IV) reduction and toxicity in yeast is partially mediated via a mitochondrial respiratory mechanism that does not encompass the generation of substantial oxidative stress. The results reported here represent a robust base from which to attack the mechanistic details of Te(IV) toxicity and reduction in a eukaryotic organism.

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“…The reduction of K 2 TeO 3 to a black insoluble compound by living tissues has long been utilized in electron microscopic investigations by pointing out the correlation between the bacterial plasma membrane and the mitochondrial inner membrane (Barrnett and Palade, 1957;van Iterson and Leene, 1964;Smith, 1974;Taylor, 1999;Klonowska et al, 2005;Massardo et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…The capacity to reduce Te is not restricted to prokaryotes, but also eukaryotes, including fungi, yeasts, plants and animal tissues that may carry out various reactions leading to form black Te 0 precipitates (Barrnett and Palade, 1957;Nagai, 1965;Corfield and Smith, 1970;Smith, 1974;Gharieb and Gadd, 1998;Ollivier et al, 2008;Zannoni et al, 2008;Massardo et al, 2009). Tucker et al (1962) demonstrated by X-ray diffraction analysis that the black precipitate produced in bacterial cells grown in potassium tellurite medium consisted of metallic tellurium (Te 0 ).…”

Section: Introductionmentioning

confidence: 97%