2015
DOI: 10.1016/j.ejphar.2014.12.008
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Telmisartan ameliorates cisplatin-induced nephrotoxicity by inhibiting MAPK mediated inflammation and apoptosis

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Cited by 106 publications
(72 citation statements)
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“…The MAPK pathway is an important signal transduction pathway that links extracellular signals to intracellular processes and is highly associated with apoptosis and inflammation. 35 We found that JNK and p38 MAPK were both phosphorylated in response to exposure to 0.05-μm microbeads. In the copepod T. japonicus, p38 MAPK has been shown to be activated in response to ultraviolet B (UVB) radiation and copper exposure.…”
Section: Environmental Science and Technologymentioning
confidence: 89%
“…The MAPK pathway is an important signal transduction pathway that links extracellular signals to intracellular processes and is highly associated with apoptosis and inflammation. 35 We found that JNK and p38 MAPK were both phosphorylated in response to exposure to 0.05-μm microbeads. In the copepod T. japonicus, p38 MAPK has been shown to be activated in response to ultraviolet B (UVB) radiation and copper exposure.…”
Section: Environmental Science and Technologymentioning
confidence: 89%
“…It is recognized that oxidative stress acts as an important pathogenic factor in causing cisplatin-induced acute kidney injury (Malik et al, 2015;Hagar et al, 2015). Normally, inside the cell, mitochondria produce ROS such as superoxides, hydroxyl and hydrogen peroxide regularly via electron transport chain but they are also simultaneously scavenged by anti-oxidant enzymessuperoxide dismutase, glutathione-s-transferase, catalase and glutathione peroxidase (Richter et al, 1995).…”
Section: Discussionmentioning
confidence: 99%
“…We observed that cisplatin at the dose of 8 mg/kg; i.p. was found to be the most optimum dose for inducing nephrotoxicity in rats and this dose of cisplatin was subsequently used to induce nephrotoxicity in rats (Malik et al, 2015).…”
Section: Experimental Protocolmentioning
confidence: 99%
“…18,24,25 Inside the tubular cells, cisplatin is aquated into a highly reactive electrophile, which rapidly reacts with thiol-containing molecules including glutathione. It also induces mitochondrial dysfunction and increases ROS production by disrupting the respiratory chain.…”
Section: Discussionmentioning
confidence: 99%
“…This dose (8 mg/kg) of cisplatin was selected on the basis of its efficacy in causing nephrotoxicity in rats. 18 In all the groups, all the animals were anaesthetized with pentobarbitone sodium (60 mg/kg; i.p.) on the 10th day of treatment.…”
Section: Methodsmentioning
confidence: 99%