Telmisartan impairs the in vitro osteogenic differentiation of mesenchymal stromal cells from spontaneously hypertensive male rats

Brito, Victor Gustavo Balera; Patrocinio, Mariana Sousa; Barreto, Ayná Emanuelli Alves; Frasnelli, Sabrina Cruz Tfaile; Lara, Vanessa Soares; Santos, Carlos; Oliveira, Sandra Helena Penha de

doi:10.1016/j.ejphar.2021.174609

Cited by 1 publication

(1 citation statement)

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“…Furthermore, ALP activity was measured on days 7 and 14 of osteogenic induction (Figure D). On day 14, a decrease in ALP activity was observed in the SA group, which is likely attributed to the poorer cell growth status, resulting in decreased osteogenic differentiation . In the SSF group, consistently, the highest expression of ALP activity was observed, significantly surpassing the other two groups.…”

Section: Resultsmentioning

confidence: 91%

Elastic 3D-Printed Nanofibers Composite Scaffold for Bone Tissue Engineering

Cai,

Li,

Ding

et al. 2023

ACS Appl. Mater. Interfaces

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Loading nanoparticles into hydrogels has been a conventional approach to augment the printability of ink and the physicochemical characteristics of scaffolds in three-dimensional (3D) printing. However, the efficacy of this enhancement has often proven to be limited. We amalgamate electrospun nanofibers with 3D printing techniques to fabricate a composite scaffold reminiscent of a "reinforced concrete" structure, aimed at addressing bone defects. These supple silica nanofibers are synthesized through a dual-step process involving high-speed homogenization and low-temperature ball milling technology. The nanofibers are homogeneously blended with sodium alginate to create the printing ink. The resultant ink was extruded seamlessly, displaying commendable molding properties, thereby yielding scaffolds with favorable macroscopic morphology. In contrast to nanoparticle-reinforced scaffolds, composite scaffolds containing nanofibers exhibit superior mechanical attributes and bioactivity. These nanofiber composite scaffolds demonstrate enhanced osteoinductive properties in both in vitro and in vivo evaluations. To conclude, this research introduces a novel 3D printing approach where the fabricated nanofiber-infused 3D-printed scaffolds hold the potential to revolutionize the realm of 3D printing in the domain of bone tissue engineering.

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Section: Resultsmentioning

confidence: 91%