Telocytes and inflammation: A review

Zhang, Yuhua; Tian, Hu

doi:10.1097/md.0000000000035983

Cited by 2 publications

(2 citation statements)

References 86 publications

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“…These Tps display a distinctive moniliform structure, comprising alternating narrow segments termed podomers and dilated regions referred to as podoms. Telocytes have been widely found in different tissues, including gut, urinary system, cardiovascular system, skin, and skeletal muscle, as reviewed 12 by Yuhua Zhang and Hu Tian. Telocytes have been demonstrated to express CD34 and PDGFRA (PDGFRα) 11 , 12 , and in one investigation, the labeling of PDGFRα was utilized for the identification of telocytes within gut tissue 11 .…”

Section: Introductionmentioning

confidence: 99%

“…Telocytes have been widely found in different tissues, including gut, urinary system, cardiovascular system, skin, and skeletal muscle, as reviewed 12 by Yuhua Zhang and Hu Tian. Telocytes have been demonstrated to express CD34 and PDGFRA (PDGFRα) 11 , 12 , and in one investigation, the labeling of PDGFRα was utilized for the identification of telocytes within gut tissue 11 . Notably, telocytes were also recently found in the testes across multiple species, including humans 13 , mice 14 , and rats 15 .…”

Section: Introductionmentioning

confidence: 99%

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Single-cell transcriptome profiling highlights the importance of telocyte, kallikrein genes, and alternative splicing in mouse testes aging

Guo,

Zhang,

Kang

et al. 2024

Sci Rep

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Advancing healthcare for elderly men requires a deeper understanding of testicular aging processes. In this study, we conducted transcriptomic profiling of 43,323 testicular single cells from young and old mice, shedding light on 1032 telocytes—an underexplored testicular cell type in previous research. Our study unveiled 916 age-related differentially expressed genes (age-DEGs), with telocytes emerging as the cell type harboring the highest count of age-DEGs. Of particular interest, four genes (Klk1b21, Klk1b22, Klk1b24, Klk1b27) from the Kallikrein family, specifically expressed in Leydig cells, displayed down-regulation in aged testes. Moreover, cell-type-level splicing analyses unveiled 1838 age-related alternative splicing (AS) events. While we confirmed the presence of more age-DEGs in somatic cells compared to germ cells, unexpectedly, more age-related AS events were identified in germ cells. Further experimental validation highlighted 4930555F03Rik, a non-coding RNA gene exhibiting significant age-related AS changes. Our study represents the first age-related single-cell transcriptomic investigation of testicular telocytes and Kallikrein genes in Leydig cells, as well as the first delineation of cell-type-level AS dynamics during testicular aging in mice.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Single-cell transcriptome profiling highlights the importance of telocyte, kallikrein genes, and alternative splicing in mouse testes aging

Guo,

Zhang,

Kang

et al. 2024

Sci Rep

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Immunohistochemical and Ultrastructural Characterization of Telocytes in Normal and Diabetic Human Kidneys

Valente,

Villacampa Lahoz,

Vasuri

et al. 2024

Biomolecules

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Background: Telocytes are interstitial stromal cells identified in various human organs, including the kidney. Their presence and role in human diabetic kidney disease remain unknown. Methods: To identify and localize telocytes in glomerular and tubule-interstitial compartments, both normal and diabetic human renal tissues were examined using immunohistochemistry, immunofluorescence, and transmission electron microscopy. Results: Renal telocytes are elongated interstitial cells with long, thin telopodes, showing alternating thin and thick segments. They expressed CD34, Nestin, α-SMA, and Vimentin markers. Occasionally, c-Kit expression was observed in some rounded and spindle cells, while no positivity was detected for PDGFR-β and NG2. Telocytes were identified around Bowman’s capsule, tubules, and peritubular capillaries in both normal and diabetic conditions. In diabetic renal samples, there was a significant increase in α-SMA expressing telocytes, leading to periglomerular fibrosis. These telocytes also exhibited a synthetic phenotype with proteoglycan deposition in the extracellular matrix and, in some cases, showed pre-adipocytic differentiation. Conclusions: Telocytes were identified in normal and diabetic human kidneys. These cells form an elastic mechanical scaffold in the interstitium and are present in all renal cortical compartments. In diabetic samples, their increased α-SMA expression and synthetic phenotype suggest their potential role in the pathogenesis of diabetic nephropathy.

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Telocytes and inflammation: A review

Cited by 2 publications

References 86 publications

Single-cell transcriptome profiling highlights the importance of telocyte, kallikrein genes, and alternative splicing in mouse testes aging

Single-cell transcriptome profiling highlights the importance of telocyte, kallikrein genes, and alternative splicing in mouse testes aging

Immunohistochemical and Ultrastructural Characterization of Telocytes in Normal and Diabetic Human Kidneys

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