Telocytes in gastric lamina propria of the Chinese giant salamander, Andrias davidianus

Zhang, Hui; Zhong, Shengwei; Yu, Peng; Ge, Tingting; Peng, Shasha; Guo, Xiaoquan; Zhou, Ziyan

doi:10.1038/srep33554

Cited by 12 publications

(7 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the current study, all TCs in the efferent ductules of camel were CD34, VEGF and vimentin positive. Camel TCs express CD34 similar immunophenotype of TCs in other mammalian species 42 as well as avian species 59 , reptiles 50 , amphibians 60 and clitellates species 2 . CD34/PDGFR-α has been identified as a specific marker for TCs 61 .…”

Section: Discussionmentioning

confidence: 70%

Morphological changes of telocytes in camel efferent ductules in response to seasonal variations during the reproductive cycle

Abdel-Maksoud

Abd‐Elhafeez

Soliman

2019

Sci Rep

View full text Add to dashboard Cite

Telocytes (TCs) are a distinct stromal cell type described in many organs. The present study investigated the existence of TCs within the efferent ductules in camel and the changes that occur in their morphology and activity during active and inactive reproductive seasons. TCs in the camel had a cell body and multiple telopodes (TPs), and most TCs had indented nuclei that exhibited prominent intranucleolar chromatin. TCs exhibited seasonal differences which were evaluated by histochemistry, immunohistochemistry (IHC), Transimition electron microscopy (TEM) and scanning electron microscopy (SEM). The presence of TCs in camel efferent ductules has been confirmed by CD34 positive immunostaing. In addition to the expression of the vascular endothelial growth factor (VEGF) which was stronger in the summer season. TCs exhibited stronger immunoreactivity for progesterone and oestrogen alpha receptors (ESR1) in the spring than in the summer. In addition, TCs showed strong positive immunostaining for both vimentin and androgen receptor (AR). Several ultrastructural changes were observed in TCs during the two seasons. TPs in the summer season had delicate ramifications whereas, in the spring, TPs displayed fine arborization and became more corrugated. TCs acquired signs of exaggerated secretory activities in the spring; TPs became expanded and packed with secretory vesicles. Thus, we conclude that, hormonal alterations during the reproductive cycle impact the morphology and secretory behavior of TCs.

show abstract

Section: Discussionmentioning

confidence: 70%

Morphological changes of telocytes in camel efferent ductules in response to seasonal variations during the reproductive cycle

Abdel-Maksoud

Abd‐Elhafeez

Soliman

2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Furthermore, TCs secrete extracellular vesicles that play an important role in supporting tissue repair/regeneration and nurse function, intercellular signaling, cell differentiation [16], homeostasis maintenance, and transport and release of lipids, proteins, as well as nucleic acids, in order to meet the target tissue requirements [17][18][19][20][21]. This communication is achieved by releasing the microRNA-filled extracellular vesicles from TCs/Tps to regulate cell functions [22].…”

Section: Introductionmentioning

confidence: 99%

Identification of Telocytes in the Pancreas of Turtles—A role in Cellular Communication

Gandahi

Ding

Shi

et al. 2020

IJMS

View full text Add to dashboard Cite

The existence of telocytes (TCs) has not yet been established in the pancreases of aquatic reptiles. Here, we report TCs in the exocrine pancreas of Pelodiscus sinensis using transmission electron microscope (TEM), immunohistochemistry (IHC), and immunofluorescence (IF) techniques. TCs surrounded the acini and ducts of the connective tissue of the exocrine pancreas and between lobules and gland cells. The cells were located preferably close to the blood vessels, interlobular ducts, and nerve fibers. Ultrastructurally, TCs exhibited small and large bodies with thick and thin portions, podoms, and podomers, and prolongations that form dichotomous branching with hetero-cellular and homo-cellular junctions. The podom (thick) portions showed caveolae, mitochondria, rough endoplasmic reticulum, and vesicles. The nucleus carries heterochromatin and is irregular in shape. The shape of TCs depends on the number of telopodes (Tps) bearing long, short, spindle, triangular, and “beads on a string” shapes with twisted, tortuous prolongations and ramifications. Shed extracellular vesicles and exosomes were found frequently released from projections and Tps within connective tissue in the vicinity of the acini and collagen fibers. IHC and IF results showed CD34+, α-SMA+, and vimentin+, long and triangle-shaped TCs, consistent with the TEM findings. The presence of shaded vesicles from TCs might implicate their possible role in immune surveillance, tissue regeneration as well as regulatory functions in the reptilian pancreas.

show abstract

“…Ultrastructural evidences of telocytes in ileum were found in the Chinese giant salamander Andrias davidianus (amphibian; Zhang et al, ). In the reptile Pelodiscus sinensis , known as Chinese soft‐shelled turtle, novel interstitial cells were found in the testis of the males (Yang et al, ), and similar cells were observed in the uterus of the oviduct in the female these animals (Ullah et al, ).…”

Section: Discussionmentioning

confidence: 99%

Presence, localization and morphology of TELOCYTES in developmental gonads of fishes

Mazzoni

Viadanna

Quagio-Grassiotto

2019

Journal of Morphology

View full text Add to dashboard Cite

Telocytes are a new defined type of interstitial cells, considered as a stem cell, with very long and thin cytoplasmic extensions. They are present in the vertebrates, and may participate in tissue remodeling. In fish, during gonadal development, the events that culminate with the germinal epithelium formation are well known. However, the interstitial compartment remains poorly explored, although it may have a great contribution to the morpho-functional changes that occur in the gonad. As in other organisms, in fish, the interstitium consists especially of connective tissue elements. However, until now, there are no reports of the presence and the action of the telocytes in the connective tissue of gonads of fish. Thus, this study aimed to detect the presence, localization and morphology of telocytes during the gonadal development of several species of fish. The gonads were analyzed by light microscopy, transmission electron microscopy and immunohistochemistry for localization of CD34, Vimentin, and metalloproteinases. The presence of two proteins characteristics of mesenchymal cell was detected in cells of the gonads of all species. In addition, they presented a typical morphology of telocytes, showing cellular extensions. Gonadal telocytes also presented positive response to metalloproteinases. In mammals, telocytes can undergo de-differentiation contributing to the reorganization of the extracellular matrix. This role may be performed by the metalloproteinases detected here. The detection of Vimentin and CD34in the same cellular type, associated with its morphological characteristics, allows us to conclude that some interstitial cells in Teleostei are considered telocytes, identical to the ones already described in mammals and other vertebrates. K E Y W O R D Sgonadal remodeling, interstitial cell, Teleostei, telocyte

show abstract

Telocytes in gastric lamina propria of the Chinese giant salamander, Andrias davidianus

Cited by 12 publications

References 40 publications

Morphological changes of telocytes in camel efferent ductules in response to seasonal variations during the reproductive cycle

Morphological changes of telocytes in camel efferent ductules in response to seasonal variations during the reproductive cycle

Identification of Telocytes in the Pancreas of Turtles—A role in Cellular Communication

Presence, localization and morphology of TELOCYTES in developmental gonads of fishes

Contact Info

Product

Resources

About