Telomerase activity in oral cancer

Miyoshi, Yoshiko; Tsukinoki, Keiichi; Imaizumi, Tomoko; Yamada, Yoichi; Ishizaki, T; Watanabe, Yoshihisa; Sasakura, Yuuichi; Lin, Yi; Hosaka, Masahiko; Kubota, Yoshinobu

doi:10.1016/s1368-8375(98)00117-1

Cited by 41 publications

(41 citation statements)

References 8 publications

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“…Liao et al 17 have reported telomerase activation in 82.1% of oral squamous cell carcinoma patients, whereas Miyoshi et al 18 demonstrate telomerase activation in 95.2% of oral squamous cell carcinoma patients. Similarly, a well-conducted study by Califano et al 19 reported telomerase activation in 80% of malignant tissues; whereas Zhang et al 20 have observed high telomerase activity in 86% of tumors.…”

Section: Discussionmentioning

confidence: 99%

Clinical usefulness of telomerase activation and telomere length in head and neck cancer

et al. 2002

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Section: Discussionmentioning

confidence: 99%

Clinical usefulness of telomerase activation and telomere length in head and neck cancer

et al. 2002

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“…TA positivity rates in cancers of the head and neck region have been reported to range from 75 to 96.6% [3][4][5]13,17,18,20,23,25,30,32,35 . Our study obtained a high TA positivity rate of 96.2% in malignant lesions, whereas all normal control gingival tissues had weak Student's t-test showed significant differences in TA between Grades I and III ( Ã P ¼ 0:0247) and Grades I and II þ III ( ÃÃ P ¼ 0:0371) of WHO classification, but no significant difference among Grades of YK classification.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, a higher TA is associated with a poorer prognosis; therefore, the level of TA is considered to reflect the grade of malignancy 10 . Nearly all previous studies have qualitatively assessed TA positivity rates or semiquantitatively evaluated relative TA [3][4][5]13,17,18,20,23,25,29,30,32 .…”

Section: Research and Emerging Technologiesmentioning

confidence: 99%

Clinical significance and usefulness of quantification of telomerase activity in oral malignant and nonmalignant lesions

Fujita

Nakagawa

Hoshina

et al. 2004

International Journal of Oral and Maxillofacial Surgery

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“…with clinical outcome in human cancers (8)(9)(10). The marked association of telomerase activity with malignant tissue provides strong evidence that telomerase activity may serve as a significant marker for diagnosing cancer.…”

Section: Increased Telomerase Activity and Htert Expression In Human mentioning

confidence: 99%

Increased telomerase activity and hTERT expression in human salivary gland carcinomas

et al. 2011

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Abstract. Approximately 85% of human malignant tumors express increased levels of telomerase. The marked association of telomerase activity with malignant tissue provides strong evidence that telomerase activity is a significant marker for the diagnosis of cancer. In this study, telomerase activity was examined in 12 benign salivary gland tumors (8 pleomorphic adenomas and 4 adenolymphomas), 24 malignant tumors (15 mucoepidermoid carcinomas, 6 adenoid cystic carcinomas and 3 acinic cell carcinomas) and 6 nonneoplastic salivary glands. The mRNA expression of the human telomerase reverse transcriptase (hTERT) and additional telomerase-associated proteins (hTEP1, p23, Hsp90 and dyskerin) was also examined. Of the 24 malignant tumors, 15 revealed strong telomerase activity. The non-neoplastic salivary glands appeared to have a negative telomerase expression. Furthermore, telomerase activity was significantly higher in high-grade mucoepidermoid carcinomas compared to low-grade ones (Student's t-test, p<0.05). A significant correlation was found between telomerase activity and mRNA expression of hTERT in 15 cases, including non-neoplastic salivary glands and tumors (Spearman's rank correlation test, p<0.05). Furthermore, a significant correlation was found between telomerase activity and mRNA expression of EGFR (Spearman's rank correlation test, p<0.001). The results suggest that not only hTERT, but also EGFR play a significant role in the activation of telomerase. In conclusion, the results suggest that telomerase activity and hTERT/EGFR mRNA expression are useful markers for the detection of malignant cells in salivary gland carcinomas. Moreover, our results indicated that telomerase activity determines the degree of malignancy of mucoepidermoid carcinoma.

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Telomerase activity in oral cancer

Cited by 41 publications

References 8 publications

Clinical usefulness of telomerase activation and telomere length in head and neck cancer

Clinical usefulness of telomerase activation and telomere length in head and neck cancer

Clinical significance and usefulness of quantification of telomerase activity in oral malignant and nonmalignant lesions

Increased telomerase activity and hTERT expression in human salivary gland carcinomas

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