Telomerase activity in the human breast

Mokbell, K.; Parris, C.N.; Ghilchik, M.W.; Newbold, Robert F.

doi:10.1054/brst.1999.0034

Cited by 11 publications

(10 citation statements)

References 11 publications

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“…It is known that activation of telomerase is associated with cell immortalization and malignancy. Telomerase reactivation appears to constitute a relatively early event in invasive breast carcinogenesis [76][77][78]. However, in DCIS, telomerase activity may be a late event associated with invasion of the basement membrane [78].…”

Section: Discussionmentioning

confidence: 99%

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The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome

Salhab

Jiang

Newbold

et al. 2007

Breast Cancer Res Treat

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Genes encoding telomere-associated proteins display different patterns of mRNA expression in human breast cancer, and in normal breast tissue, suggesting different and sometimes opposing roles in mammary carcinogenesis. hTERT, hTR, TANK1, EST1 and TEP1 seem to be up-regulated, with hTERT and TEP1 correlating with clinical outcome. Conversely, TANK2 and POT1 transcription levels demonstrate a compelling trend to be lower in malignant tissues and lower still in those patients who develop recurrent disease suggesting that TANK2 and POT1 may act as tumour suppressor genes possibly by negatively regulating telomerase activity.

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Section: Discussionmentioning

confidence: 99%

“…Telomerase reactivation appears to constitute a relatively early event in invasive breast carcinogenesis [76][77][78]. However, in DCIS, telomerase activity may be a late event associated with invasion of the basement membrane [78]. Hiyama et al detected telomerase activity in 95% of advanced stage breast cancer specimens.…”

Section: Discussionmentioning

confidence: 99%

The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome

Salhab

Jiang

Newbold

et al. 2007

Breast Cancer Res Treat

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“…Similarly, the proliferative advantage hypothesis requires the adoption of unlikely assumptions. First, in apparent disregard of telomere-shortening-imposed limits on cellular multiplication (reviewed in Wright and Shay 2002) and findings suggesting that telomerase activation is a late event in human tumourigenesis (Bachor et al 1999, Mokbell et al 1999, it requires that potentially malignant cells be able to complete very large numbers of divisions in order to accumulate significant numbers of mutations (Tomlinson 2001). Second, despite an apparent lack of evidence for proliferative changes preceding the appearance of colorectal adenoma (reviewed in Jass 1993), it requires that the potentially malignant cell accumulate specific mutations that progressively provide a considerable increase in proliferative advantage (Tomlinson 2001).…”

Section: Evidence That Gene Mutations Might Notmentioning

confidence: 99%

Chromosomal rearrangement as the basis for human tumourigenesis

2004

International Journal of Radiation Biology

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A novel model of tumourigenesis was developed that includes three basic postulates: (1) tumourigenesis is initiated by recombinogenic DNA lesions, (2) potentially recombinogenic DNA lesions in transcribed regions of the genome can be converted into chromosomal rearrangements and (3) chromosomal rearrangements alone are insufficient for tumourigenesis but can initiate a mutator/recombinator phenotype.

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“…Moreover, methods concerning detection of enzymes such as telomerase [4,5] in malignancy are well known by us.We have initiated a study to evaluate telomerase activity, metal proteins, and Ki-67 expression on nipple discharge fluids in patients with breast cancer. At the moment, though, our number of case studies must be expanded, to give valuable final results and conclusions.…”

mentioning

confidence: 99%

“…Moreover, methods concerning detection of enzymes such as telomerase [4,5] in malignancy are well known by us.…”

mentioning

confidence: 99%

Reply to Drs. Leris, Kouriefs, Williams, and Mokbel

Gioffré-Florio

2000

J. Surg. Oncol.

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In response to the letter by Leris et al. "Assessment of Nipple Discharge" [1] and in reference to our article [2], we are aware of the recent studies that demonstrate the importance of nipple discharge fluid through its complex biochemical and cellular composition-revealing alveolar gland aspects.Phillips et al. [3] have demonstrated that samples of breast ductal fluid obtained by nipple aspiration make possible cytological examination by molecular and biological techniques. Moreover, methods concerning detection of enzymes such as telomerase [4,5] in malignancy are well known by us.We have initiated a study to evaluate telomerase activity, metal proteins, and Ki-67 expression on nipple discharge fluids in patients with breast cancer. At the moment, though, our number of case studies must be expanded, to give valuable final results and conclusions.We believe that studies of telomerase activity give superior results compared to other methods used in the past. REFERENCES1. Leris C, Kouriefs C, Williams N, et al.: Assessment of nipple discharge [letter]. J Surg Oncol 2000;75:72. 2. Gioffre' Florio MA, Manganaro T, et al.: Surgical approach to nipple discharge: A ten-year experience. J Surg Oncol 1999;71: 235-238. 3. Phillips HA, Howard GCW, Miller WR: Nipple aspirate fluid in relation to breast cancer. Breast 1999;8:169-174. 4. Mokbel K, Parris CN, Ghilchik M, et al.: The association between telomerase, histological parameters and Ki-67 expression in breast cancer. Am J Surg 1999;178:68-72. 5. Mokbell K, Parris CN, Ghilchik M: Telomerase activity in the human breast. Breast 1999;8:208-211.

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Telomerase activity in the human breast

Cited by 11 publications

References 11 publications

The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome

The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome

Chromosomal rearrangement as the basis for human tumourigenesis

Reply to Drs. Leris, Kouriefs, Williams, and Mokbel

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