Telomerase activity is spontaneously increased in lymphocytes from patients with atopic dermatitis and correlates with cellular proliferation

Wu, Kaida; Volke, Annika; Lund, Marianne; Bang, Karen; Thestrup‐Pedersen, Kristian

doi:10.1016/s0923-1811(99)00039-0

Cited by 16 publications

(22 citation statements)

References 22 publications

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“…Previously we have reported that telomerase activity is spontaneously increased in blood lymphocytes from AD patients and correlates with cellular proliferation (21). In the present study we demonstrate that there is a significant increase in telomerase activity of CD4 ϩ and CD8 ϩ T cells from peripheral blood together with a reduced telomere length of lymphocytes, indicating that a major portion of the lymphocytes have gone through a high number of cell divisions in vivo.…”

supporting

confidence: 72%

Telomerase Activity Is Increased and Telomere Length Shortened in T Cells from Blood of Patients with Atopic Dermatitis and Psoriasis

Higashi

Hansen

et al. 2000

The Journal of Immunology

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We studied telomerase activity and telomere length in PBMC and purified CD4+ and CD8+ T cells from blood obtained from a total of 32 patients with atopic dermatitis, 16 patients with psoriasis, and 30 normal controls. The telomerase activity was significantly increased in PBMC from the patients compared with PBMC from normal donors. This increase was most pronounced in the subpopulation of CD4+ T cells, which were significantly above the activity of the CD8+ T cells in atopic dermatitis, psoriasis patients, and control persons. The telomere length was significantly reduced in all T cell subsets from both atopic dermatitis and psoriasis patients compared with normal individuals. Furthermore, the telomere length was found to be significantly shorter in CD4+ memory T cells compared with the CD4+ naive T cells, and both of the cell subsets from diseases were shown to be of significantly shorter telomere length than the same cell subsets from normal controls. No significant difference was observed between CD8+CD28− and CD8+CD28+ T cell populations in both diseases. However, the telomere length of CD8+CD28+ T cells from both diseases was significantly shorter than CD8+CD28+ T cell subsets from normal donors. In conclusion, the increased telomerase activity and shortened telomere length indicates that T lymphocytes in atopic dermatitis and psoriasis are chronically stimulated and have an increased cellular turnover in vivo.

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confidence: 72%

Telomerase Activity Is Increased and Telomere Length Shortened in T Cells from Blood of Patients with Atopic Dermatitis and Psoriasis

Higashi

Hansen

et al. 2000

The Journal of Immunology

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“…Increased expression of telomerase has been observed in activated lymphocytes and in PBMCs of systemic connective tissue diseases and atopic dermatitis. [15][16][17] In addition, the expression of telomerase in lymphocytes is correlated with cellular proliferation. 17 It may be assumed that telomerase expression in PBMCs of head and neck cancer patients also is somehow related to the proliferation of lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

“…[15][16][17] In addition, the expression of telomerase in lymphocytes is correlated with cellular proliferation. 17 It may be assumed that telomerase expression in PBMCs of head and neck cancer patients also is somehow related to the proliferation of lymphocytes. These reports are consistent with the study that telomerase expression in tissue or cells represents a biomarker of the proliferation of cells, rather than a biomarker of malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Value of Telomerase Expression in Peripheral Blood Mononuclear Cells of Head and Neck Cancer Patients

Lee¹,

Wang²,

Choi³

et al. 2006

American Journal of Clinical Oncology

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“…Detection of telomerase activity in these normal proliferating somatic cells suggests that telomerase activity is associated not only with tumorigenic transformation but also with the proliferation state of the cells (11). In addition, telomerase activity is increased in blood lymphocytes from atopic dermatitis patients and correlates with cellular proliferation (9). In normal tissues like fibroblasts in which proliferation is generally absent, telomerase activity to maintain the tissue integrity is not required (10).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, telomerase activity was used as a marker for residual or recurrence of tumor (5). Recently, there is increasing evidence that telomerase activity is associated with cell proliferation without malignancy (6)(7)(8)(9). Skin samples that had low levels of telomerase activity and uroepithelial cells that had no detectable telomerase activity were shown to have greatly elevated levels of telomerase activity when these cells were cultured (10,11).…”

Section: Introductionmentioning

confidence: 99%

Detection of Telomerase Activity in Psoriasis Lesional Skin and Correlaton with Ki-67 Expression and Suppression by Retinoic Acid

Jang

et al. 2001

J Korean Med Sci

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Telomerase activity is usually detected in most tumor tissues but not in normal tissues. Recently, there is increasing evidence that telomerase activity is associated with cell proliferation without malignancy, whereas there is little information about telomerase activity and its relationship with cell proliferation in chronic hyperproliferative skin diseases. Thus, we studied telomerase activity in skins from 10 patients with psoriasis and compared telomerase activity with the expression of Ki-67, a proliferation marker, using immunohistochemical staining. The effect of retinoic acid on the telomerase activity in HaCaT cells was also evaluated. Telomerase activity was detected in 7 (70%) of 10 lesional skins of psoriasis and none of the nonlesional skin. Telomerase activity in lesional skin was significantly associated with Ki-67 labelling index. Retinoic acid treatment on HaCaT cells inhibited telomerase activity, which correlated with inhibition of cell proliferation by the agent. The results of our study represent another example that shows telomerase activity correlates with cellular proliferation. Further studies on the regulation of the telomerase are needed to understand the cellular factors involved in controlling telomerase activity.

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Telomerase activity is spontaneously increased in lymphocytes from patients with atopic dermatitis and correlates with cellular proliferation

Cited by 16 publications

References 22 publications

Telomerase Activity Is Increased and Telomere Length Shortened in T Cells from Blood of Patients with Atopic Dermatitis and Psoriasis

Telomerase Activity Is Increased and Telomere Length Shortened in T Cells from Blood of Patients with Atopic Dermatitis and Psoriasis

The Prognostic Value of Telomerase Expression in Peripheral Blood Mononuclear Cells of Head and Neck Cancer Patients

Detection of Telomerase Activity in Psoriasis Lesional Skin and Correlaton with Ki-67 Expression and Suppression by Retinoic Acid

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