Telomerase Expression in Individuals With Chronic and Aggressive Periodontitis

Katarkar, Atul; Arindam, Saha; Mukherjee, Sanjit; Kundu, Debtosh; Bandyopadhyay, Prasanta; Chaudhuri, Keya

doi:10.1902/jop.2015.140540

Cited by 12 publications

(8 citation statements)

References 46 publications

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“…146 Also, increased expression of the human telomerase reverse transcription (hTERT) enzyme has been noticed in patients with periodontitis. 147,148 Carcinogenesis is a multi-step process. Genetic alterations and different signaling pathways result in cell proliferation, resistance to apoptosis, invasion and metastasis.…”

Section: Genetic Alterations and The Risk Of Periodontitis Development And Carcinogenesismentioning

confidence: 99%

Periodontitis and oral cancer - current concepts of the etiopathogenesis

Irani¹,

Barati²,

Badiei³

2020

Oncol Rev

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Gingival tissues are attacked by oral pathogens which can induce inflammatory reactions. The immune-inflammatory responses play essential roles in the patient susceptibility to periodontal diseases. There is a wealth of evidence indicating a link between chronic inflammation and risk of malignant transformation of the affected oral epithelium. Periodontitis is associated with an increased risk of developing chronic systemic conditions including autoimmune diseases and different types of cancers. Besides, some risk factors such as smoking , alcohol consumption and human papilloma virus have been found to be associated with both periodontitis and oral cancer. This review article aimed to study the current concepts in pathogenesis of chronic periodontitis and oral cancer by reviewing the related articles.

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Section: Genetic Alterations and The Risk Of Periodontitis Development And Carcinogenesismentioning

confidence: 99%

Periodontitis and oral cancer - current concepts of the etiopathogenesis

Irani¹,

Barati²,

Badiei³

2020

Oncol Rev

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“…Periodontal diseases have also been involved in the elevated risk of the cancer occurrence by overexpression of the human telomerase reverse transcription (hTERT) enzyme that was identified in patients with periodontitis. This result strongly suggests that both periodontitis and cancer are linked in disease-oriented pathways to progress to cellular differentiation and immortality (Refs 52,53).…”

Section: Extra-oral Cancermentioning

confidence: 86%

Oral microbiota in cancer: could the bad guy turn good with application of polyphenols?

Antoniraj

Devi

Berindan‐Neagoe

et al. 2022

Expert Rev. Mol. Med.

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The human oral cavity is comprised of dynamic and polynomial microbes which uniquely reside in the microenvironments of oral cavities. The cumulative functions of the symbiotic microbial communities maintain normal homeostasis; however, a shifted microbiota yields a dysbiosis state, which produces local and systemic diseases including dental caries, periodontitis, cancer, obesity and diabetes. Recent research reports claim that an association occurs between oral dysbiosis and the progression of different types of cancers including oral, gastric and pancreatic ones. Different mechanisms are proposed for the development of cancer, such as induction of inflammatory reactions, production of carcinogenic materials and alteration of the immune system. Medications are available to treat these associated diseases; however, the current strategies may further worsen the disease by unwanted side effects. Natural-derived polyphenol molecules significantly inhibit a wide range of systemic diseases with fewer side effects. In this review, we have displayed the functions of the oral microbes and we have extended the report regarding the role of polyphenols in oral microbiota to maintain healthy conditions and prevention of diseases with emphasis on the treatment of oral microbiota-associated cancer.

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“…15,16 In the same way, aerodigestive cancer mortality has been shown to be elevated according to the severity of periodontitis. 17 Additionally, periodontal disease was demonstrated that the probability of having an oral leukoplakia experience grows in a dose-dependent manner, directly proportional to the gravity of periodontitis. Likewise, association with gingival inflammation, measured by bleeding on probing scores, was identified in patients with leukoplakia.…”

Section: Dear Editormentioning

confidence: 99%